Evidence map›Paper›PMID 29875145›Full record

ArticlemSphere2018

Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform.

Julie Liao, Jacob A Gibson, Bradley S Pickering, Paula I Watnick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Julie LiaoDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jacob A GibsonDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Bradley S PickeringNational Centre for Foreign Animal Diseases, Canadian Food Inspection Agency, Government of Canada, Canadian Science Centre for Human and Animal Health, Winnipeg, Manitoba, Canada.
Paula I WatnickDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA paula.watnick@childrens.harvard.edu.ORCID 0000-0002-9173-8662
Boston Children's Hospital · USCanadian Food Inspection Agency · CA

Funding

The role of proteolysis in bacterial biofilm formationR21AI115023 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WATNICK, PAULA I · 2015 to 2016
$486k
Biofilm matrix-based vaccinesR21AI115303 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WATNICK, PAULA I · 2015 to 2016
$486k
NIAID NIH HHS R21 AI115023NIAID NIH HHS R21 AI115303
6 · The paper itself

Abstract

A sublingually delivered heterologous antigen presentation platform that does not depend on antigen or adjuvant purification would be of great benefit in protection against diarrheal disease. In proof-of-concept studies, we previously showed that when a fusion protein comprised of the

Indexed as

Antigen PresentationAdjuvants, ImmunologicAdministration, SublingualAnimalsAntibodies, BacterialAntigens, BacterialCholeraCholera VaccinesEnzyme-Linked Immunosorbent AssayFecesFemaleImmunity, MucosalImmunoglobulin AImmunoglobulin GMice, Inbred BALB CVaccines, AttenuatedAdjuvants, ImmunologicAntibodies, BacterialAntigens, BacterialCholera VaccinesImmunoglobulin AImmunoglobulin GVaccines, AttenuatedVaccines, Syntheticcholera toxin adjuvantslive vector vaccinesmmCTvaccinevaccine platformVibrio cholerae

Identifiers

PMID29875145
PMCPMC5990885
OpenAlexW2805814235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.