Evidence map›Paper›PMID 29875144›Full record

ArticlemSphere2018

Hsp90 Is Essential for Chl1-Mediated Chromosome Segregation and Sister Chromatid Cohesion.

Nidhi Khurana, Sayan Bakshi, Wahida Tabassum, Mrinal K Bhattacharyya, Sunanda Bhattacharyya

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nidhi KhuranaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Sayan BakshiDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Wahida TabassumDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Mrinal K BhattacharyyaDepartment of Biochemistry, School of Life Sciences, University of Hyderabad, Hyderabad, India.
Sunanda BhattacharyyaDepartment of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, India sdeb70@gmail.com.
University of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have demonstrated that aberrant sister chromatid cohesion causes genomic instability and hence is responsible for the development of a tumor. The Chl1 (chromosome loss 1) protein (homolog of human ChlRl/DDX11 helicase) plays an essential role in the proper segregation of chromosomes during mitosis. The helicase activity of Chl1 is critical for sister chromatid cohesion. Our study demonstrates that Hsp90 interacts with Chl1 and is necessary for its stability. We observe that the Hsp90 nonfunctional condition (temperature-sensitive

Indexed as

Chromosome SegregationChromosomes, HumanChromatidsChromosomal Proteins, Non-HistoneHSP90 Heat-Shock ProteinsHumansProtein BindingProtein Interaction MappingProtein StabilityProteolysisSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTwo-Hybrid System TechniquesCHL1 protein, S cerevisiaeChromosomal Proteins, Non-HistoneHSP82 protein, S cerevisiaeHSP90 Heat-Shock ProteinsSaccharomyces cerevisiae ProteinsChl1chromosome segregationHsp90sister chromatid cohesion

Identifiers

PMID29875144
PMCPMC5990887
OpenAlexW2806456860

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.