Evidence map›Paper›PMID 29874923›Full record

ArticleActa radiologica (Stockholm, Sweden : 1987)2019

Endovascular thrombectomy in anterior circulation stroke and clinical value of bridging with intravenous thrombolysis.

Arturs Balodis, Maija Radzina, Evija Miglane, Anthony Rudd, Andrejs Millers, Janis Savlovskis, Karlis Kupcs

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PubMed Full text at PMC Publisher
In one paragraph

Article in Acta radiologica (Stockholm, Sweden : 1987), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 5 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke due to large vessel occlusion; should we cross that bridge? A systematic review and meta-analysis of 36,123 patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  3. Pooled it
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  5. Pooled it
  6. Trial
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Arturs Balodis1 Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia.ORCID https://orcid.org/0000-0002-7457-1901
Maija Radzina1 Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia.
Evija Miglane3 Department of Neurology Paula Stradina Clinical University Hospital, Riga, Latvia.
Anthony Rudd4 King's College London, London Stroke Director, London, UK.
Andrejs Millers3 Department of Neurology Paula Stradina Clinical University Hospital, Riga, Latvia.
Janis Savlovskis1 Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia.
Karlis Kupcs1 Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia.
Pauls Stradiņš Clinical University Hospital · LVKing's College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBridging treatment with intravenous thrombolysis (IVT) before endovascular thrombectomy (EVT) in acute ischemic stroke is applied under the assumption of benefits for patients with large vessel occlusion (LVO). However, the benefit of this additional step has not yet been proven. PURPOSE: To compare procedural parameters (procedural time, number of attempts), complications, and clinical outcome in patients receiving EVT vs. patients with bridging treatment. MATERIAL AND

methodsIn this prospective study all patients had acute anterior cerebral circulation occlusion and were treated with EVT. All patients were selected for treatment based on clinical criteria, multimodal computed tomography (CT) imaging. Eighty-four patients were treated with bridging IVT followed by EVT; 62 patients were treated with EVT only.

resultsBridging therapy did not influence endovascular procedure time ( P = 0.71) or number of attempts needed ( P = 0.63). Bleeding from any site was more common in the bridging group (27, 32%) vs. the EVT group (12, 19%) ( P = 0.09). Functional independence modified Rankin Scale after 90 days was slightly higher in the bridging group (44%) vs. the EVT group (42%) ( P = 0.14). Mortality did not differ significantly at 90 days: 17% in the bridging group vs. 21% in EVT alone ( P = 0.57). Both treatment methods showed high recanalization rates: 94% in the bridging group and 89% for EVT alone.

conclusionBridging treatment in LVO did not show benefits or elevated risks of complications in comparison to EVT only. The bridging group did not show significantly better neurological outcome or significant impact on procedural parameters vs. EVT alone.

Indexed as

AgedCerebral AngiographyCombined Modality TherapyComputed Tomography AngiographyEndovascular ProceduresFemaleHumansMaleOperative TimePostoperative ComplicationsProspective StudiesRetreatmentStrokeThrombectomyThrombolytic TherapyTomography, X-Ray ComputedbridgingCT perfusionhemorrhagestrokeThrombectomythrombolysis

Identifiers

PMID29874923
PMCPMC6378397
OpenAlexW2805059076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.