ReviewInternational journal of molecular sciences2018
Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Retrorsine impairs liver regeneration by inducing progenitor cell-senescenceAnnals of medicine · 2026Article
- Metabolic Activation-Dependent Anti-Liver Cancer Activity and Organ-Specific Toxicity of Retrorsine From Fanhuncao (Jacobaea cannabifolia and J. litvinovii).Archiv der Pharmazie · 2026Article
- Defined Natural Products as Adjunctive Therapies: Evidence-Gated Polypharmacology Across Molecular Targets, Human Exposure, Clinical Signals, and Safety Boundaries.International journal of molecular sciences · 2026Review
- Cocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling.Antioxidants (Basel, Switzerland) · 2026Review
- Pyrrolizidine Alkaloid-Induced Hepatotoxicity: A Narrative Review on Molecular Mechanisms and Detoxification Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Diversity in seed fatty acid composition and petal pyrrolizidine alkaloid content in Echium amoenum Fisch. & C.A.Mey. populations.BMC plant biology · 2026Article
- Antiviral activity of the aqueous extract of twelve monthly-collections of propolis from Barra do Corda.Scientific reports · 2026Article
- Chemotaxonomy and Ecological Role of Pyrrolizidine Alkaloids: A Comprehensive Review of the Case Study of Africa.Journal of chemical ecology · 2026Review
- Synergistic wound healing mechanisms of Heliotropium curassavicum extracts via redox modulation, inflammation suppression, and tissue remodeling: linking phytochemical diversity to antioxidant and anti-inflammatory effects.Inflammopharmacology · 2026Article
- Hepatic Sinusoidal Obstruction Syndrome Induced by Pyrrolizidine Alkaloids fromMolecules (Basel, Switzerland) · 2026Review
- Aryl hydrocarbon receptor: a potential target for natural products in the treatment of inflammatory bowel disease.Frontiers in immunology · 2026Review
- Effect of diode laser power settings on calcium loss in acid-eroded dentin: an in-vitro analysis.Scientific reports · 2025Article
- [Determination of 35 pyrrolizidine alkaloids in dried tea by ultra-high performance liquid chromatography- triple quadrupole mass spectrometry].Se pu = Chinese journal of chromatography · 2025Article
- Tropane and Pyrrolizidine Alkaloids in Edible Flowers and Flower-Derived Foods: A Food Safety Perspective.Foods (Basel, Switzerland) · 2025Review
- A Review of the Main Biologically Active Compounds of the GenusPharmaceuticals (Basel, Switzerland) · 2025Review
- Screening of Mediterranean Plant-Derived Extracts for Antioxidant Effect in Cell-Free and Human Cell Line Models.Antioxidants (Basel, Switzerland) · 2025Article
- Evaluation of the toxicity of essential oil ofToxicology research · 2025Article
- Liquid Gold with a Dark Side-A Toxicological Overview of Bioactive Components in Honey.Molecules (Basel, Switzerland) · 2025Review
- Uncovering the poisonous aconitine containing plants in homemade herbal liquor using a convergent approach.Scientific reports · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrrolizidine alkaloids (PA) are widely distributed in plants throughout the world, frequently in species relevant for human consumption. Apart from the toxicity that these molecules can cause in humans and livestock, PA are also known for their wide range of pharmacological properties, which can be exploited in drug discovery programs. In this work we review the current body of knowledge regarding the chemistry, toxicology, pharmacology and food safety of PA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.