Evidence map›Paper›PMID 29874642›Full record

SynthesisCaries research2019

The Effect of Silver Diamine Fluoride in Preventing Caries in the Primary Dentition: A Systematic Review and Meta-Analysis.

Branca Heloisa Oliveira, Anjana Rajendra, Analia Veitz-Keenan, Richard Niederman

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Caries research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04354636 (Clinical and Radiographic Evaluation After the Use of Silver Modified Atraumatic Restorative Treatment Versus Atraumatic Restorative Treatment in the Management of Occlusal Caries of Primary Molars in Preschool Children), which is not on this map. Cited by 69 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 5 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04354636 phase2 / phase3completednot on this mapstarted 2021, after this paper: background citation

Clinical and Radiographic Evaluation After the Use of Silver Modified Atraumatic Restorative Treatment Versus Atraumatic Restorative Treatment in the Management of Occlusal Caries of Primary Molars in Preschool Children: Randomized Clinical Trial

TypeinterventionalSponsorCairo UniversityRan2021 to 2023Enrolled50ConditionsOcclusal CariesArmsSilver modified atraumatic restorative treatment, Atraumatic restorative treatment
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 184 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Influence of knowledge about silver diamine fluoride on the acceptance and perception of Brazilian children's guardians: a randomized controlled clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Effects of Bleaching Protocols on the Esthetic Outcome and Surface Integrity of Enamel Treated With an Ammonia-Free Silver Fluoride Solution.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
    Article
  15. Knowledge, attitude and practice of paediatric dentists towards silver diammine fluoride in Egypt: a national survey.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  16. Silver diamine fluoride for non-operative restorative treatment and prevention of dental caries.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026
    Review
  17. Article
  18. Article
  19. Review
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Branca Heloisa OliveiraDepartment of Community and Preventive Dentistry, Faculty of Dentistry, University of the State of Rio de Janeiro, Rio de Janeiro, Brazilbranca@uerj.br.
Anjana RajendraDepartment of Epidemiology and Health Promotion, College of Dentistry, New York University, New York, New York, USA.
Analia Veitz-KeenanDepartment of Oral and Maxillofacial Pathology, Radiology and Medicine, College of Dentistry, New York University, New York, New York, USA.
Richard NiedermanDepartment of Epidemiology and Health Promotion, College of Dentistry, New York University, New York, New York, USA.
New York University · USYork University · US

Funding

Effectiveness and improvement of rural, school-based, caries prevention programsU24MD006964 · NIMHD · NEW YORK UNIVERSITY · PI NIEDERMAN, RICHARD · 2011 to 2015
$6.3M
Statewide implementation and evaluation of a rural, school-based, caries prevention programR01MD011526 · NIMHD · NEW YORK UNIVERSITY · PI NIEDERMAN, RICHARD, RUFF, RYAN RICHARD · 2017 to 2021
$3.6M
NIMHD NIH HHS R01 MD011526NIMHD NIH HHS U24 MD006964
6 · The paper itself

Abstract

objectivesTo investigate whether silver diamine fluoride (SDF) is effective in preventing new caries lesions in primary teeth when compared to placebo or active treatments.

methodsSystematic review (CRD42016036963) of controlled clinical trials. Searches were performed in 9 electronic databases, 5 registers of ongoing trials, and reference lists of identified review articles. Two researchers carried out data extraction and quality appraisal independently. The primary outcome was the difference in caries increment (decayed, missing, and filled surfaces or teeth - dmfs or dmft) between SDF and control groups. These differences were pooled as weighted mean differences (WMD) and prevented fractions (PF).

resultsSearches yielded 2,366 unique records; 6 reports of 4 trials that randomized 1,118 and analyzed 915 participants were included. Two trials compared SDF to no treatment, 1 compared SDF to placebo and sodium fluoride varnish (FV), and 1 compared SDF to high-viscosity glass ionomer cement (GIC). All studies had at least 1 domain with unclear or high risk of bias. After 24 months of follow-up, in comparison to placebo, no treatment, and FV, SDF applications significantly reduced the development of new dentin caries lesions (placebo or no treatment: WMD = -1.15, PF = 77.5%; FV: WMD = -0.43, PF = 54.0%). GIC was more effective than SDF after 12 months of follow-up but the difference between them was not statistically significant (WMD, dmft: 0.34, PF: -6.09%).

conclusionWhen applied to caries lesions in primary teeth, SDF compared to no treatment, placebo or FV appears to effectively prevent dental caries in the entire dentition. However, trials specifically designed to assess this outcome are needed.

Indexed as

Cariostatic AgentsChildChild, PreschoolControlled Clinical Trials as TopicDental CariesFluorides, TopicalFollow-Up StudiesGlass Ionomer CementsHumansInflammationQuaternary Ammonium CompoundsSilver CompoundsSodium FluorideTaste DisordersTooth, DeciduousTooth DiscolorationCariostatic AgentsFluorides, TopicalGlass Ionomer CementsQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluorideSodium FluorideCariostatic agentsDental cariesPreventive dentistrySilver diamine fluorideSystematic review

Identifiers

PMID29874642
PMCPMC6292783
OpenAlexW2811259881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.