Evidence map›Paper›PMID 29874625›Full record

ArticleStem cell reports2018

Proliferation versus Differentiation: Redefining Retinoic Acid's Role.

Kira Irving Mosher, David V Schaffer

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Roles of vitamins in stem cells.Cellular and molecular life sciences : CMLS · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kira Irving MosherCalifornia Institute for Quantitative Biosciences, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: kmosher@berkeley.edu.
David V SchafferCalifornia Institute for Quantitative Biosciences, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Chemical and Biomolecular Engineering, University of California at Berkeley, Berkeley, CA 94720, USA; Department of Bioengineering, University of California at Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: schaffer@berkeley.edu.
QB3 · US

Funding

Optogenetic Characterization and Control of Stem Cell SignalingR01NS087253 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KANE, RAVI S., SCHAFFER, DAVID V · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS087253
6 · The paper itself

Abstract

Retinoic acid is commonly used in culture to differentiate stem cells into neurons and has established neural differentiation functions in vivo in developing and adult organisms. In this issue of Stem Cell Reports, Mishra et al. (2018) broaden its role in stem cell functions, showing that retinoic acid is necessary for stem and progenitor cell proliferation in the adult brain.

Indexed as

Age FactorsCell DifferentiationCell ProliferationHippocampusStem CellsTretinoinTretinoin

Identifiers

PMID29874625
PMCPMC6117460
OpenAlexW2806314439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.