ArticleCell reports2018
Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- Broadband amplification of organ of Corti vibrations in the mouse cochlear apex.bioRxiv : the preprint server for biology · 2026Article
- Cancer therapy-induced ototoxicity: Current challenges and emerging management strategies.Animal models and experimental medicine · 2026Review
- Optical coherence tomography imaging demonstrates endolymphatic hydrops in the lateral and posterior semicircular canals in noise-exposed mice.Hearing research · 2025Article
- Sound-evoked tonic motility of cochlear outer hair cells in mice with stereociliary defects.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Medial Olivocochlear Efferent Pathway Potentiates Cochlear Amplification in Response to Hearing Loss.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Gating-spring stiffness increases outer-hair-cell bundle stiffness, damping, and receptor current.Scientific reports · 2024Article
- Semicircular canal drug delivery safely targets the inner ear perilymphatic space.JCI insight · 2024Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Local cochlear mechanical responses revealed through outer hair cell receptor potential measurements.Biophysical journal · 2024Article
- Regional differences in cochlear nonlinearity across the basal organ of Corti of gerbil: Regional differences in cochlear nonlinearity.Hearing research · 2024Article
- Linear mixed-effect modeling of organ of Corti vibratory tuning curves.Hearing research · 2023Article
- Bandpass Shape of Distortion-Product Otoacoustic Emission Ratio Functions Reflects Cochlear Frequency Tuning in Normal-Hearing Mice.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea.Scientific reports · 2022Article
- The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification.Journal of neurophysiology · 2022Article
- A Gap-Junction Mutation Reveals That Outer Hair Cell Extracellular Receptor Potentials Drive High-Frequency Cochlear Amplification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea.Hearing research · 2022Article
- Salicylate-induced changes in organ of Corti vibrations.Hearing research · 2022Article
- Outer hair cell driven reticular lamina mechanical distortion in living cochleae.Hearing research · 2022Review
- Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea.Biophysical journal · 2022Article
- Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
The stereociliary bundles of cochlear hair cells convert mechanical vibrations into the electrical signals required for auditory sensation. While the stiffness of the bundles strongly influences mechanotransduction, its influence on the vibratory response of the cochlear partition is unclear. To assess this, we measured cochlear vibrations in mutant mice with reduced bundle stiffness or with a tectorial membrane (TM) that is detached from the sensory epithelium. We found that reducing bundle stiffness decreased the high-frequency extent and sharpened the tuning of vibratory responses obtained postmortem. Detaching the TM further reduced the high-frequency extent of the vibrations but also lowered the partition's resonant frequency. Together, these results demonstrate that the bundle's stiffness and attachment to the TM contribute to passive longitudinal coupling in the cochlea. We conclude that the stereociliary bundles and TM interact to facilitate passive-wave propagation to more apical locations, possibly enhancing active-wave amplification in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.