Evidence map›Paper›PMID 29874567›Full record

Trial reportCell metabolism2018

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota.

Francesca Cignarella, Claudia Cantoni, Laura Ghezzi, Amber Salter, Yair Dorsett, Lei Chen, Daniel Phillips, George M Weinstock, Luigi Fontana, Anne H Cross and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05200468 (Effect of Intermittent Fasting, Caloric Restriction and Ketogenic Diet on Mitochondrial Function and Gut Microbiota in Subjects With Obesity), which is not on this map. Cited by 313 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed, 12 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05200468 nacompletednot on this mapstarted 2022, after this paper: background citation

Effect of Intermittent Fasting, Caloric Restriction and Ketogenic Diet on Mitochondrial Function and Gut Microbiota in Subjects With Obesity

TypeinterventionalSponsorInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranRan2022 to 2023Enrolled63ConditionsObesityArmsKetogenic diet, Caloric restriction diet, Intermittent fasting 16/8
3 · Its place in the literature

Who cites it

313 citing papers in PubMed, 12 syntheses or guidelines pooled it, 549 citations in OpenAlex.

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253 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Francesca CignarellaDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Claudia CantoniDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Laura GhezziDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA; Neurology Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Milan, Italy.
Amber SalterDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yair DorsettJackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Lei ChenJackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Daniel PhillipsJackson Laboratory for Genomic Medicine, Farmington, CT, USA.
George M WeinstockJackson Laboratory for Genomic Medicine, Farmington, CT, USA.
Luigi FontanaDepartment of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Clinical and Experimental Sciences, Brescia University Medical School, Brescia, Italy; CEINGE Biotecnologie Avanzate, Napoli, Italy.
Anne H CrossDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA.
Yanjiao ZhouJackson Laboratory for Genomic Medicine, Farmington, CT, USA. Electronic address: yazhou@uchc.edu.
Laura PiccioDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Avenue, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA. Electronic address: picciol@wustl.edu.
Jackson Laboratory · USWashington University in St. Louis · USHope Center for Neurological Disorders · USUniversity of Brescia · ITUniversity of Milan · IT

Funding

Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Intermittent Fasting-induced Gut Microbiome Modulation of CNS AutoimmunityR01NS102633 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI ZHOU, YANJIAO · 2017 to 2022
$2.1M
CONSTRUCTION OF EXTRAMURAL RESEARCH FACILITIESC06RR014513 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FISCHBACH, GERALD D · 1999 to 1999
–
NCRR NIH HHS C06 RR014513NIDDK NIH HHS P30 DK056341NINDS NIH HHS R01 NS102633
6 · The paper itself

Abstract

Multiple sclerosis (MS) is more common in western countries with diet being a potential contributing factor. Here we show that intermittent fasting (IF) ameliorated clinical course and pathology of the MS model, experimental autoimmune encephalomyelitis (EAE). IF led to increased gut bacteria richness, enrichment of the Lactobacillaceae, Bacteroidaceae, and Prevotellaceae families and enhanced antioxidative microbial metabolic pathways. IF altered T cells in the gut with a reduction of IL-17 producing T cells and an increase in regulatory T cells. Fecal microbiome transplantation from mice on IF ameliorated EAE in immunized recipient mice on a normal diet, suggesting that IF effects are at least partially mediated by the gut flora. In a pilot clinical trial in MS patients, intermittent energy restriction altered blood adipokines and the gut flora resembling protective changes observed in mice. In conclusion, IF has potent immunomodulatory effects that are at least partially mediated by the gut microbiome.

Indexed as

AutoimmunityEncephalomyelitis, Autoimmune, ExperimentalFastingGastrointestinal MicrobiomeMultiple SclerosisAdipokinesAdultAnimalsBacteroidaceaeCentral Nervous SystemFemaleHumansLactobacillaceaeMiceMice, Inbred C57BLMiddle AgedAdipokinesdietexperimental autoimmune encephalomyelitisgut microbiotaintermittent fastingmultiple sclerosis

Identifiers

PMID29874567
PMCPMC6460288
OpenAlexW2806113892

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.