ReviewNeuroscience and biobehavioral reviews2018
Early life stress, air pollution, inflammation, and disease: An integrative review and immunologic model of social-environmental adversity and lifespan health.
Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- A systematic review of air pollution exposure and brain structure and function during development.Environmental research · 2025Pooled it
- Ambient air pollution and COVID-19 risk: Evidence from 35 observational studies.Environmental research · 2022Pooled it
- Trial
- From genes to environment: A life-course approach to prevent pediatric autoimmune diseases.World journal of clinical pediatrics · 2026Review
- Adverse childhood experiences (ACEs) moderate the association between traffic exposure and circulating inflammatory biomarkers.Brain, behavior, & immunity - health · 2026Article
- Inflammatory diet mediates the relationship between early life stress and inflammation in adolescents.Brain, behavior, and immunity · 2026Article
- Advancing women's mental health: Recommendations from a National Academies of Sciences, Engineering, and Medicine workshop.PNAS nexus · 2026Article
- Local Violence as an Environmental Exposure with Increasing Relevance under Climate Change: A Conceptual Framework.Journal of urban health : bulletin of the New York Academy of Medicine · 2026Review
- Social determinants of vulnerability to nitrogen oxide- and sulfur dioxide-related bone damage among postmenopausal women in the United States.Frontiers in public health · 2026Article
- Gestational phthalate levels and biomarkers of aging in infants and children from New York City.Environmental research · 2025Article
- Advances in plant-derived vesicle like nanoparticles-based therapies for inflammatory diseases.Asian journal of pharmaceutical sciences · 2025Review
- The perspective of socially vulnerable youth on healthcare services: a Portuguese cross-sectional study.Archives of public health = Archives belges de sante publique · 2025Article
- Association between Prenatal Particulate Matter Exposure and Neuropsychiatric Disorders Development.Biomolecules & therapeutics · 2025Review
- Sensitive periods for exposure to indoor air pollutants and psychosocial factors in association with symptoms of psychopathology at school-age in a South African birth cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Bridging the gap: Integrating exercise mimicry into chronic disease management through suppressing chronic inflammation.Journal of advanced research · 2025Review
- Evidence for Environmental Risk Factors and Cumulative Stress Linking Racial/Ethnic Identity and Psychotic-Like Experiences in ABCD Study Data.Journal of the American Academy of Child and Adolescent Psychiatry · 2025Article
- Sensitivity to Environmental Stress and Adversity and Lung Cancer.JAMA network open · 2025Article
- Adolescent morphine exposure does not alter low-dose lipopolysaccharide (LPS)-induced sickness behavior in adult C57/BL6 mice.PloS one · 2025Article
- Effects of higher dietary acid load: a narrative review with special emphasis in children.Pediatric nephrology (Berlin, Germany) · 2025Review
- Joint effects of indoor air pollution and maternal psychosocial factors during pregnancy on trajectories of early childhood psychopathology.American journal of epidemiology · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Socially disadvantaged individuals are at greater risk for simultaneously being exposed to adverse social and environmental conditions. Although the mechanisms underlying joint effects remain unclear, one hypothesis is that toxic social and environmental exposures have synergistic effects on inflammatory processes that underlie the development of chronic diseases, including cardiovascular disease, diabetes, depression, and certain types of cancer. In the present review, we examine how exposure to two risk factors that commonly occur with social disadvantage-early life stress and air pollution-affect health. Specifically, we identify neuroimmunologic pathways that could link early life stress, inflammation, air pollution, and poor health, and use this information to propose an integrated, multi-level model that describes how these factors may interact and cause health disparity across individuals based on social disadvantage. This model highlights the importance of interdisciplinary research considering multiple exposures across domains and the potential for synergistic, cross-domain effects on health, and may help identify factors that could potentially be targeted to reduce disease risk and improve lifespan health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.