ArticlePLoS biology2018
The bench is closer to the bedside than we think: Uncovering the ethical ties between preclinical researchers in translational neuroscience and patients in clinical trials.
Article in PLoS biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- More ethics in the laboratory, please! Scientists' perspectives on ethics in the preclinical phase.Accountability in research · 2025Article
- Reframing the perception of outliers and negative data in translational research.Brain research bulletin · 2023Review
- External validity in translational biomedicine: understanding the conditions enabling the cause to have an effect.EMBO molecular medicine · 2022Article
- Using the concept of "deserved trust" to strengthen the value and integrity of biomedical research.Accountability in research · 2021Article
- Do we really know how many clinical trials are conducted ethically? Why research ethics committee review practices need to be strengthened and initial steps we could take to strengthen them.Journal of medical ethics · 2021Review
- Moving towards less biased research.BMJ open science · 2021Article
- Translational Block in Stroke: A Constructive and "Out-of-the-Box" Reappraisal.Frontiers in neuroscience · 2021Article
- Evaluation of Nutritional Gel Supplementation in C57BL/6J Mice Infected with Mouse-Adapted Influenza A/PR/8/34 Virus.Comparative medicine · 2020Article
- fiddle: a tool to combat publication bias by getting research out of the file drawer and into the scientific community.Clinical science (London, England : 1979) · 2020Article
- Rescuing Informed Consent: How the new "Key Information" and "Reasonable Person" Provisions in the Revised U.S. Common Rule open the door to long Overdue Informed Consent Disclosure Improvements and why we need to walk Through that door.Science and engineering ethics · 2020Article
- Joining forces: the need to combine science and ethics to address problems of validity and translation in neuropsychiatry research using animal models.Philosophy, ethics, and humanities in medicine : PEHM · 2020Article
- Identifying and understanding factors that affect the translation of therapies from the laboratory to patients: a study protocol.F1000Research · 2020Article
- Rethinking research reproducibility.The EMBO journal · 2019Article
- [Interdisciplinary challenges in neuromedicine].Der Nervenarzt · 2018Article
- Challenges of Conducting Risk-Benefit Analysis of Early Phase Clinical Trials: Results of a National Survey of IRB Chairs.Ethics & human researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Millions of people worldwide currently suffer from serious neurological diseases and injuries for which there are few, and often no, effective treatments. The paucity of effective interventions is, no doubt, due in large part to the complexity of the disorders, as well as our currently limited understanding of their pathophysiology. The bleak picture for patients, however, is also attributable to avoidable impediments stemming from quality concerns in preclinical research that often escape detection by research regulation efforts. In our essay, we connect the dots between these concerns about the quality of preclinical research and their potential ethical impact on the patients who volunteer for early trials of interventions informed by it. We do so in hopes that a greater appreciation among preclinical researchers of these serious ethical consequences can lead to a greater commitment within the research community to adopt widely available tools and measures that can help to improve the quality of research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.