ArticleJournal of the American Chemical Society2018
Design of a Highly Bistable Photoswitchable Tethered Ligand for Rapid and Sustained Manipulation of Neurotransmission.
Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Orchestrating photoswitch thermal backconversion using hydrogen bonds to reshape energy landscapes.Nature communications · 2026Article
- Triplet Spin Delocalization and Temperature Dependence for Adiabatic and Non-AdiabaticJournal of the American Chemical Society · 2025Article
- Optogenetics with Atomic Precision─A Comprehensive Review of Optical Control of Protein Function through Genetic Code Expansion.Chemical reviews · 2025Review
- Arylazobenzimidazoles: versatile visible-light photoswitches with tuneableChemical science · 2024Article
- Photopharmacology of Ion Channels through the Light of the Computational Microscope.International journal of molecular sciences · 2021Review
- Chemoproteomics-Enabled De Novo Discovery of Photoswitchable Carboxylesterase Inhibitors for Optically Controlled Drug Metabolism.Angewandte Chemie (International ed. in English) · 2021Article
- Article
- Visible Light Mediated Bidirectional Control over Carbonic Anhydrase Activity in Cells andJournal of the American Chemical Society · 2020Article
- Article
- Photopotentiation of the GABAProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Optical control of neuronal ion channels and receptors.Nature reviews. Neuroscience · 2019Review
- A photoswitchable GABA receptor channel blocker.British journal of pharmacology · 2019Article
- Locked-Azobenzene: Testing the Scope of a Unique Photoswitchable Scaffold for Cell Physiology.ACS chemical neuroscience · 2019Article
- pH-Dependent Morphology and Photoresponse of Azopyridine-Terminated Poly(Macromolecules · 2019Article
- Azologization of serotonin 5-HTBeilstein journal of organic chemistry · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Photoswitchable neurotransmitter receptors are powerful tools for precise manipulation of neural signaling. However, their applications for slow or long-lasting biological events are constrained by fast thermal relaxation of cis-azobenzene. We address this issue by modifying the ortho positions of azobenzene used in the tethered ligand. In cultured cells and intact brain tissue, conjugating inhibitory neurotransmitter receptors with one of the derivatives, dMPC1, allows bidirectional receptor control with 380 and 500 nm light. Moreover, the receptors can be locked in either an active or an inactive state in darkness after a brief pulse of light. This strategy thus enables both rapid and sustained manipulation of neurotransmission, allowing optogenetic interrogation of neural functions over a broad range of time scales.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.