Evidence map›Paper›PMID 29874058›Full record

ArticleJournal of the American Chemical Society2018

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A

Matthew T Eddy, Zhan-Guo Gao, Philip Mannes, Nilkanth Patel, Kenneth A Jacobson, Vsevolod Katritch, Raymond C Stevens, Kurt Wüthrich

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 49 citations in OpenAlex.

  1. The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Switchbody, an Antigen-Responsive Enzyme Switch Based on Antibody and Its Working Principle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Membrane mimetic-dependence of GPCR energy landscapes.Structure (London, England : 1993) · 2024
    Article
  5. Single-molecule visualization of human ACommunications biology · 2023
    Article
  6. Membrane Mimetic-Dependence of GPCR Energy Landscapes.bioRxiv : the preprint server for biology · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Anionic Phospholipids Control Mechanisms of GPCR-G Protein Recognition.bioRxiv : the preprint server for biology · 2023
    Article
  13. AInternational review of neurobiology · 2023
    Article
  14. Article
  15. Review
  16. Adenosine ABritish journal of pharmacology · 2022
    Review
  17. Review
  18. Review
  19. Review
  20. Slow conformational dynamics of the human AStructure (London, England : 1993) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthew T EddyDepartment of Integrative Structural and Computational Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.ORCID 0000-0002-3349-6212
Zhan-Guo GaoLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.
Philip MannesLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.
Nilkanth PatelBridge Institute, Departments of Biological Sciences and Chemistry, Michelson Center , University of Southern California , Los Angeles , California 90089 , United States.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.ORCID 0000-0001-8104-1493
Vsevolod KatritchBridge Institute, Departments of Biological Sciences and Chemistry, Michelson Center , University of Southern California , Los Angeles , California 90089 , United States.ORCID 0000-0003-3883-4505
Raymond C StevensBridge Institute, Departments of Biological Sciences and Chemistry, Michelson Center , University of Southern California , Los Angeles , California 90089 , United States.
Kurt WüthrichDepartment of Integrative Structural and Computational Biology , The Scripps Research Institute , 10550 North Torrey Pines Road , La Jolla , California 92037 , United States.ORCID 0000-0003-2612-6616
University of Southern California · USNational Institutes of Health · USScripps Research Institute · US

Funding

Project 3U54GM094618 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI STEVENS, RAYMOND C · 2010 to 2014
$17.1M
Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Dynamics of the Opioid Receptor Signaling ComplexR01GM115825 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI WUTHRICH, KURT · 2015 to 2018
$1.7M
Drugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854k
Intramural NIH HHS Z01 DK031117Intramural NIH HHS ZIA DK031117NIGMS NIH HHS R01 GM115825NIGMS NIH HHS U54 GM094618
6 · The paper itself

Abstract

Tryptophan indole

Indexed as

Nuclear Magnetic Resonance, BiomolecularHumansLigandsMembrane ProteinsMolecular ProbesPichiaReceptor, Adenosine A2ATryptophanADORA2A protein, humanLigandsMembrane ProteinsMolecular ProbesReceptor, Adenosine A2ATryptophan

Identifiers

PMID29874058
PMCPMC6192543
OpenAlexW2805466774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.