Evidence map›Paper›PMID 29873837›Full record

ReviewEuropean journal of clinical investigation2018

Calcium signalling and related ion channels in neutrophil recruitment and function.

Roland Immler, Scott I Simon, Markus Sperandio

Open access · bronzeAbstract readReview
In one paragraph

Review in European journal of clinical investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 145 citations in OpenAlex.

  1. Trial
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  11. Neutrophil store-operated CaJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  12. Review
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  20. Neutrophils-biology and diversity.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
    Review

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Roland ImmlerWalter Brendel Centre of Experimental Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.
Scott I SimonDepartment of Biomedical Engineering, Graduate Group in Immunology, University of California, Davis, CA, USA.
Markus SperandioWalter Brendel Centre of Experimental Medicine, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.ORCID http://orcid.org/0000-0002-7689-3613
Ludwig-Maximilians-Universität München · DEUniversity of California, Davis · US

Funding

Outside-in Mechanotransduced Inflammatory TargetsR01AI047294 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, SCOTT IRWIN · 1999 to 2021
$7.0M
Engineering the innate immune response to Staphaureus infectionR01AI129302 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEACH, J. KENT, SIMON, SCOTT IRWIN · 2017 to 2021
$1.9M
Deutsche Forschungsgemeinschaft SFB914, Project B1 and Z3National Institute of Allergy and Infectious Diseases AI047924National Institute of Allergy and Infectious Diseases AI129302NIAID NIH HHS R01 AI047294NIAID NIH HHS R01 AI129302United States National Institute of Health AI047924United States National Institute of Health AI129302
6 · The paper itself

Abstract

The recruitment of neutrophils to sites of inflammation, their battle against invading microorganisms through phagocytosis and the release of antimicrobial agents is a highly coordinated and tightly regulated process that involves the interplay of many different receptors, ion channels and signalling pathways. Changes in intracellular calcium levels, caused by cytosolic Ca

Indexed as

AnimalsCalcium ChannelsCalcium SignalingHumansIon ChannelsMiceNeutrophil InfiltrationNeutrophilsPotassium ChannelsReceptors, Purinergic P2XSodium ChannelsTransient Receptor Potential ChannelsCalcium ChannelsHv1 proton channel, mouseIon ChannelsPotassium ChannelsReceptors, Purinergic P2XSodium ChannelsTransient Receptor Potential Channelscalcium channelscalcium signallingCRAC channelsleucocyte recruitment cascadeneutrophilOrai1P2X receptorspotassium channelsSOCESTIM1TRP channels

Identifiers

PMID29873837
PMCPMC6221920
OpenAlexW2805433484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.