Evidence map›Paper›PMID 29873835›Full record

ReviewJournal of leukocyte biology2018

Decoding the chemotactic signal.

Monica A Thomas, Andrew B Kleist, Brian F Volkman

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. KArchiv der Pharmazie · 2026
    Article
  2. Article
  3. Article
  4. Two endogenousProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. A short critique on biomining technology for critical materials.World journal of microbiology & biotechnology · 2021
    Review
  9. Using Live-Cell Imaging and Synthetic Biology to Probe Directed Migration inFrontiers in cell and developmental biology · 2021
    Review
  10. Review
  11. Role of LrrkA in the Control of Phagocytosis and Cell Motility inFrontiers in cell and developmental biology · 2021
    Article
  12. Article
  13. Transcriptional Responses ofFrontiers in microbiology · 2020
    Article
  14. Extracellular signaling in Dictyostelium.The International journal of developmental biology · 2019
    Review
  15. Article
  16. Decoding the chemotactic signal.Journal of leukocyte biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Monica A ThomasDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Andrew B KleistDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Brian F VolkmanDepartment of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Medical College of Wisconsin · US

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Structural Basis for Chemokine FunctionR01AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2004 to 2019
$4.1M
Structural Basis for Chemokine FunctionR37AI058072 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI Brian F Volkman · 2020 to 2026
$2.8M
Targeting CCL28 as therapy for obstructive lung diseaseR01AI120655 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI VOLKMAN, BRIAN F · 2015 to 2018
$1.5M
Structural basis of chemokine receptor signaling in tumor progressionF30CA196040 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI KLEIST, ANDREW B · 2016 to 2020
$233k
Validating CCL28 as a Target for Novel Asthma Therapies using NMR SpectroscopyF30HL134253 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI THOMAS, MONICA A · 2017 to 2019
$140k
NCI NIH HHS F30 CA196040NHLBI NIH HHS F30 HL134253NIAID NIH HHS R01 AI058072NIAID NIH HHS R01 AI120655NIAID NIH HHS R37 AI058072NIGMS NIH HHS T32 GM080202
6 · The paper itself

Abstract

From an individual bacterium to the cells that compose the human immune system, cellular chemotaxis plays a fundamental role in allowing cells to navigate, interpret, and respond to their environments. While many features of cellular chemotaxis are shared among systems as diverse as bacteria and human immune cells, the machinery that guides the migration of these model organisms varies widely. In this article, we review current literature on the diversity of chemoattractant ligands, the cell surface receptors that detect and process chemotactic gradients, and the link between signal recognition and the regulation of cellular machinery that allow for efficient directed cellular movement. These facets of cellular chemotaxis are compared among E. coli, Dictyostelium discoideum, and mammalian neutrophils to derive organizational principles by which diverse cell systems sense and respond to chemotactic gradients to initiate cellular migration.

Indexed as

AnimalsChemotaxisHumansSignal Transductionchemotaxiscommunication theoryG protein-coupled receptormethyl-accepting chemotaxis protein receptor

Identifiers

PMID29873835
PMCPMC6099250
OpenAlexW2805617375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.