Evidence map›Paper›PMID 29873782›Full record

ArticleNucleic acids research2018

Coloc-stats: a unified web interface to perform colocalization analysis of genomic features.

Boris Simovski, Chakravarthi Kanduri, Sveinung Gundersen, Dmytro Titov, Diana Domanska, Christoph Bock, Lara Bossini-Castillo, Maria Chikina, Alexander Favorov, Ryan M Layer and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Atlas of glomerular disease-specific genetic effects on blood transcriptome.medRxiv : the preprint server for health sciences · 2026
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  12. NAR genomics and bioinformatics · 2021
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  14. Review
  15. Analytical Approaches for ATAC-seq Data Analysis.Current protocols in human genetics · 2020
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  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Boris SimovskiDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.
Chakravarthi KanduriDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.
Sveinung GundersenDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.
Dmytro TitovDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.
Diana DomanskaDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.
Christoph BockCeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria.
Lara Bossini-CastilloCellular Genetics Programme, Wellcome Sanger Institute, CB10 1SA Hinxton, UK.
Maria ChikinaUniversity of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15213, USA.
Alexander FavorovDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 550 N Broadway, Baltimore, MD 21205, USA.
Ryan M LayerDepartment of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA.
Andrey A MironovFaculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Lab. Bldg B, Vorobiovy Gory 1-73, Moscow 119992, Russia.
Aaron R QuinlanDepartment of Human Genetics, University of Utah, 15 N 2030 E, Salt Lake City, UT 84112, USA.
Nathan C SheffieldCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22903 USA.
Gosia TrynkaCellular Genetics Programme, Wellcome Sanger Institute, CB10 1SA Hinxton, UK.
Geir K SandveDepartment of Informatics, University of Oslo, Gaustadalléen 23 B, N-0373 Oslo, Norway.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Monitoring tumor subclonal heterogeneity over time and spaceU24CA209999 · NCI · UNIVERSITY OF UTAH · PI MARTH, GABOR T, QUINLAN, AARON R · 2016 to 2020
$3.9M
New algorithms and tools for large-scale genomic analysesR01HG006693 · NHGRI · UNIVERSITY OF VIRGINIA · PI QUINLAN, AARON R · 2012 to 2018
$3.1M
Software for exploring all forms of genetic variation in any speciesR01GM124355 · NIGMS · UNIVERSITY OF UTAH · PI QUINLAN, AARON R · 2017 to 2020
$1.8M
A scalable, integrative, multi-omic analysis platformK99HG009532 · NHGRI · UNIVERSITY OF UTAH · PI LAYER, RYAN M · 2017 to 2018
$209k
Medical Research Council MR/N014995/1NCI NIH HHS P30 CA006973NCI NIH HHS U24 CA209999NHGRI NIH HHS K99 HG009532NHGRI NIH HHS R01 HG006693NIGMS NIH HHS R01 GM124355Wellcome Trust
6 · The paper itself

Abstract

Functional genomics assays produce sets of genomic regions as one of their main outputs. To biologically interpret such region-sets, researchers often use colocalization analysis, where the statistical significance of colocalization (overlap, spatial proximity) between two or more region-sets is tested. Existing colocalization analysis tools vary in the statistical methodology and analysis approaches, thus potentially providing different conclusions for the same research question. As the findings of colocalization analysis are often the basis for follow-up experiments, it is helpful to use several tools in parallel and to compare the results. We developed the Coloc-stats web service to facilitate such analyses. Coloc-stats provides a unified interface to perform colocalization analysis across various analytical methods and method-specific options (e.g. colocalization measures, resolution, null models). Coloc-stats helps the user to find a method that supports their experimental requirements and allows for a straightforward comparison across methods. Coloc-stats is implemented as a web server with a graphical user interface that assists users with configuring their colocalization analyses. Coloc-stats is freely available at https://hyperbrowser.uio.no/coloc-stats/.

Indexed as

SoftwareChromatin ImmunoprecipitationGATA1 Transcription FactorGenomicsInternetSequence Analysis, DNAUser-Computer InterfaceGATA1 Transcription Factor

Identifiers

PMID29873782
PMCPMC6030976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.