Evidence map›Paper›PMID 29873767›Full record

ArticleThe Journal of infectious diseases2018

Use of Whole-Genome Sequencing in the Investigation of a Nosocomial Influenza Virus Outbreak.

Catherine F Houlihan, Dan Frampton, R Bridget Ferns, Jade Raffle, Paul Grant, Myriam Reidy, Leila Hail, Kirsty Thomson, Frank Mattes, Zisis Kozlakidis and 3 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 64 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. SARS-CoV-2 genomics and impact on clinical care for COVID-19.The Journal of antimicrobial chemotherapy · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Antigenic characterization of influenza and SARS-CoV-2 viruses.Analytical and bioanalytical chemistry · 2022
    Review
  11. Article
  12. Article
  13. Real-Time Investigation of a Large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  14. Article
  15. Viral Sequencing to Investigate Sources of SARS-CoV-2 Infection in US Healthcare Personnel.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  16. Review
  17. The impact of testing and infection prevention and control strategies on within-hospital transmission dynamics of COVID-19 in English hospitals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
  18. Article
  19. Article
  20. Managing cancer during COVID pandemic - Experience of a tertiary cancer care center.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Catherine F HoulihanDivision of Infection and Immunity, University College London, London, United Kingdom.
Dan FramptonDivision of Infection and Immunity, University College London, London, United Kingdom.
R Bridget FernsDivision of Infection and Immunity, University College London, London, United Kingdom.
Jade RaffleDivision of Infection and Immunity, University College London, London, United Kingdom.
Paul GrantDepartment of Clinical Virology, UCL Hospitals National Health Service Foundation Trust, London, United Kingdom.
Myriam ReidyInfection Control Service, UCL Hospitals National Health Service Foundation Trust, London, United Kingdom.
Leila HailInfection Control Service, UCL Hospitals National Health Service Foundation Trust, London, United Kingdom.
Kirsty ThomsonDepartment of Blood Diseases, UCL Hospitals National Health Service Foundation Trust, London, United Kingdom.
Frank MattesDepartment of Clinical Virology, UCL Hospitals National Health Service Foundation Trust, London, United Kingdom.
Zisis KozlakidisDivision of Infection and Immunity, University College London, London, United Kingdom.
Deenan PillayDivision of Infection and Immunity, University College London, London, United Kingdom.
Andrew HaywardInstitute of Epidemiology and Health Care, University College London, London, United Kingdom.
Eleni NastouliDepartment of Population, Policy, and Practice, Great Ormond Street Institute of Child Health, University College London (UCL), London, United Kingdom.
University College London · GBNational Health Service · GBFarr Institute · GBNational Institute for Health Research · GB

Funding

Department of HealthWellcome Trust
6 · The paper itself

Abstract

Traditional epidemiological investigation of nosocomial transmission of influenza involves the identification of patients who have the same influenza virus type and who have overlapped in time and place. This method may misidentify transmission where it has not occurred or miss transmission when it has. We used influenza virus whole-genome sequencing (WGS) to investigate an outbreak of influenza A virus infection in a hematology/oncology ward and identified 2 separate introductions, one of which resulted in 5 additional infections and 79 bed-days lost. Results from WGS are becoming rapidly available and may supplement traditional infection control procedures in the investigation and management of nosocomial outbreaks.

Indexed as

Cross InfectionDisease OutbreaksHumansInfection ControlInfluenza A virusInfluenza, HumanMolecular EpidemiologyWhole Genome Sequencing

Identifiers

PMID29873767
PMCPMC6151078
OpenAlexW2806068948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.