ArticleNanomedicine (London, England)2018
Topical delivery of ebselen encapsulated in biopolymeric nanocapsules: drug repurposing enhanced antifungal activity.
Article in Nanomedicine (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Chemical modifications of diphenyl diselenide enhance its anti-Sporothrix spp. activity and exhibit synergism with itraconazole.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Article
- Ebselen: A Multifaceted Organoselenium Compound With Therapeutic Potential in Liver Diseases.Oxidative medicine and cellular longevity · 2026Review
- Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey.International journal of molecular sciences · 2024Review
- Ebselen: A Promising Repurposing Drug to Treat Infections Caused by Multidrug-Resistant Microorganisms.Interdisciplinary perspectives on infectious diseases · 2024Review
- Recent Advances in the Polish Research on Polysaccharide-Based Nanoparticles in the Context of Various Administration Routes.Biomedicines · 2023Review
- Review
- In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs againstPharmaceutics · 2022Article
- Toxicology and pharmacology of synthetic organoselenium compounds: an update.Archives of toxicology · 2021Review
- Azacarbazole n-3 and n-6 polyunsaturated fatty acids ethyl esters nanoemulsion with enhanced efficacy againstBioactive materials · 2021Article
- Evaluation of the In Vitro Cytotoxic Activity of Caffeic Acid Derivatives and Liposomal Formulation against Pancreatic Cancer Cell Lines.Materials (Basel, Switzerland) · 2020Article
- Antifungal Drug Repurposing.Antibiotics (Basel, Switzerland) · 2020Article
- Crosslinked polymer nanocapsules for therapeutic, diagnostic, and theranostic applications.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2020Review
- Nanoemulsion Stabilized by Safe Surfactin fromPharmaceutics · 2020Article
- Nanoscale Drug Delivery Systems: From Medicine to Agriculture.Frontiers in bioengineering and biotechnology · 2020Review
- Soft and Condensed Nanoparticles and Nanoformulations for Cancer Drug Delivery and Repurpose.Advanced therapeutics · 2020Article
- Synthesis and Antioxidant Activity of Caffeic Acid Derivatives.Molecules (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
aimEbselen (Eb) is an example of a repurposed drug with poor aqueous solubility which requires sophisticated delivery system such as nanoencapsulation in nanocapsules for topical application. MATERIALS &
methodsEb-nanocapsules were examined for morphology, activity against Candida spp., cytotoxicity and skin permeation.
resultsEb-nanocapsules were active against skin-infecting Candida tropicalis, Candida albicans and Candida parapsilosis yeasts (minimal inhibitory concentration values were about 4-, 2- and 1.25-times lower vs free Eb, respectively) and able to suppress induced lipid oxidation in the oil/water emulsion. Moreover, demonstrated minimal toxicity in normal human dermal fibroblast cell line, whereas ex vivo skin permeation studies showed no transdermal passage and strong interactions with stratum corneum.
conclusionEb-nanocapsules represent a promising, safe and complementary alternative to the treatment of cutaneous candidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.