Evidence map›Paper›PMID 29873413›Full record

ArticleMolecular carcinogenesis2018

Genetic variation in the Hippo pathway and breast cancer risk in women of African ancestry.

Shengfeng Wang, Dezheng Huo, Temidayo O Ogundiran, Oladosu Ojengbede, Wei Zheng, Katherine L Nathanson, Barbara Nemesure, Stefan Ambs, Olufunmilayo I Olopade, Yonglan Zheng

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular carcinogenesis, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 3 countries.

Shengfeng WangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois.
Temidayo O OgundiranDepartment of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Oladosu OjengbedeCenter for Population and Reproductive Health, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee.
Katherine L NathansonDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Barbara NemesureDepartment of Preventive Medicine, State University of New York at Stony Brook, Stony Brook, New York.
Stefan AmbsLaboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois.
Yonglan ZhengCenter for Clinical Cancer Genetics and Global Health, Department of Medicine, University of Chicago, Chicago, Illinois.ORCID 0000-0001-6597-7072
University of Chicago · USUniversity of Ibadan · NGChicago Department of Public Health · USGenesis Foundation · USPeking University · CNState University of New York · USUniversity of Pennsylvania · USVanderbilt University · US

Funding

Novel Markers for Disease Outcome in Breast CancerZIABC010887 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI AMBS, STEFAN · 2009 to 2025
$11.5M
Developing an Oncology Workforce for the 21st Century - Renewal 01K12CA139160 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F., SMITH, SONALI · 2010 to 2024
$10.6M
Using Genomics to Reduce Breast Cancer Disparities in the African DiasporaU01CA161032 · NCI · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2012 to 2015
$3.6M
Genome-wide association study of breast cancer in the African DiasporaR01CA142996 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2010 to 2012
$1.5M
NCI NIH HHS K12 CA139160NCI NIH HHS R01 CA142996NCI NIH HHS U01 CA161032
6 · The paper itself

Abstract

Gene expression changes within the Hippo pathway were found to be associated with large tumor size and metastasis in breast cancer. The combined effect of genetic variants in genes of this pathway may have a causal role in breast cancer development. We examined 7086 SNPs that were not highly correlated (r

Indexed as

Polymorphism, Single NucleotideBarbadosBlack or African AmericanBlack PeopleBreast NeoplasmsCase-Control StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHippo Signaling PathwayHumansMiddle AgedNigeriaProtein Serine-Threonine KinasesProtein Serine-Threonine KinasesReceptors, Estrogenadaptive joint multilocus testbreast cancerHippo pathwaySNPswomen of African ancestry

Identifiers

PMID29873413
PMCPMC6662580
OpenAlexW2805827091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.