ArticleThe clinical respiratory journal2018
Prevalence and features of asthma-COPD overlap in the United States 2007-2012.
Article in The clinical respiratory journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Pooled it
- Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- The Perception of Asthma, Chronic Obstructive Pulmonary Disease, Asthma and Chronic Obstructive Pulmonary Disease Overlap, and Cough Variant Asthma: A Retrospective Observational Study.Internal medicine (Tokyo, Japan) · 2025Observational
- Hospitalization Outcomes of Patients with Asthma, COPD, and Asthma-COPD Overlap Syndrome.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025Article
- Clinical characteristics of asthma-chronic obstructive pulmonary disease overlap phenotypes.Postepy dermatologii i alergologii · 2025Article
- Epidemiological characteristics of asthma-COPD overlap, its association with all-cause mortality, and the mediating role of depressive symptoms: evidence from NHANES 2005-2018.BMC public health · 2024Article
- PPARγ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap.Respiratory research · 2024Article
- PPARγ Attenuates Cellular Senescence of Alveolar Macrophages in Asthma- COPD Overlap.Research square · 2024Article
- Exploring the association between asthma and chronic comorbidities: impact on clinical outcomes.Frontiers in medicine · 2024Review
- Management of comorbidities in difficult and severe asthma.Breathe (Sheffield, England) · 2023Review
- Asthma, chronic obstructive pulmonary disease, and asthma-COPD overlap among US working adults.The Journal of asthma : official journal of the Association for the Care of Asthma · 2023Article
- Characteristics and difference of respiratory diseases in Korean adults aged ≥40 years: A cross-sectional study.The clinical respiratory journal · 2023Article
- Clinical outcomes among hospitalized US adults with asthma or chronic obstructive pulmonary disease, with or without COVID-19.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Article
- Blood volatile organic compounds associated with non-reversible and reversible airflow obstruction in US adults.The European respiratory journal · 2022Article
- Medication use by US patients with pulmonary hypertension associated with chronic obstructive pulmonary disease: a retrospective study of administrative data.BMC pulmonary medicine · 2022Article
- Comorbidities in childhood-onset and adult-onset asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022Article
- Sleep problems and associations with cardiovascular disease and all-cause mortality in asthma-chronic obstructive pulmonary disease overlap: analysis of the National Health and Nutrition Examination Survey (2007-2012).Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Review
- Albuminuria as a Predictor of Mortality from Chronic Lower Respiratory Disease and from Influenza and Pneumonia.Annals of the American Thoracic Society · 2021Article
- Asthma among hospitalized patients with COVID-19 and related outcomes.The Journal of allergy and clinical immunology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundPerceived to be distinct, asthma and chronic obstructive pulmonary disease (COPD) can co-exist and potentially have a worse prognosis than the separate diseases. Yet, little is known about the exact prevalence and the characteristics of the Asthma-COPD overlap (ACO) in the US population.
aimsTo determine ACO prevalence in the United States, identify ACO predictors, examine ACO association with asthma and COPD severity, and describe distinctive spirometry and laboratory features of ACO.
methodsData on adult participants to the National Health and Nutrition Examination Surveys conducted from 2007 to 2012 was analyzed. ACO was defined as current asthma and post-bronchodilator forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) <0.7.
resultsOverall, 7,570 participants representing 98.58 million Americans were included in our study. From 2007 to 2012, the crude and age-standardized ACO prevalence were, respectively, 0.96% (95% CI: 0.65%-1.26%) and 1.05% (0.74%-1.37%). In asthma, ACO predictors included older age, male gender, and smoking. In COPD, ACO predictors were non-Hispanic Black race/ethnicity and obesity. ACO was associated with increased ER visits for asthma (OR = 3.46, 95% CI: 1.48-8.06]) and oxygen therapy in COPD (OR = 11.17, 95% CI: 5.17-24.12]). In spirometry, FEV1 and peak expiratory flow were lower in ACO than in asthma or COPD alone.
conclusionAge-adjusted prevalence of ACO in the United States was 1.05% in 2007-2012, representing 0.94 (95% CI: 0.62-1.26) million Americans. It is much lower than previously reported. The overlap was associated with higher asthma and COPD severity as well as decreased lung function compared with COPD or asthma alone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.