Evidence map›Paper›PMID 29873181›Full record

ArticleMolecular oncology2018

Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4

Zhaohui Wang, Nathan J Louras, Alexandre G Lellouch, Shannon G Pratts, Huiping Zhang, Haoyu Wang, Christene A Huang, Curtis L Cetrulo, Joren C Madsen, David H Sachs and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhaohui WangCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Nathan J LourasCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Alexandre G LellouchCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Shannon G PrattsCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Huiping ZhangCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Haoyu WangCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christene A HuangCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Curtis L CetruloCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Joren C MadsenCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David H SachsCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Zhirui WangCenter for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Harvard University · US

Funding

XENOGENIC TOLERANCE IN MICEP01HL018646 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 1985 to 2019
$37.5M
Project 3: The Role of Erythropoietin in Kidney Transplant ToleranceP01AI123086 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MADSEN, JOREN C · 2016 to 2020
$10.6M
NHLBI NIH HHS P01 HL018646NIAID NIH HHS P01 AI123086
6 · The paper itself

Abstract

Recently, we have developed a diphtheria toxin-based recombinant anti-human CCR4 immunotoxin for targeting CCR4

Indexed as

AnimalsDiphtheria ToxinImmunotoxinsMacaca fascicularisMaleReceptors, CCR4Recombinant Fusion ProteinsT-Lymphocytes, RegulatoryDiphtheria ToxinImmunotoxinsReceptors, CCR4Recombinant Fusion ProteinsCCR4diphtheria toxinimmunotoxinTreg

Identifiers

PMID29873181
PMCPMC6068354
OpenAlexW2806299885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.