Evidence map›Paper›PMID 29873079›Full record

ArticleThe Journal of physiology2018

Bicarbonate directly modulates activity of chemosensitive neurons in the retrotrapezoid nucleus.

Christopher M Gonçalves, Daniel K Mulkey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Direct energy consumption by inhibitory GABAFrontiers in neuroscience · 2026
    Article
  2. Genistein and Vanadate Differentially Modulate Cortical GABAInternational journal of molecular sciences · 2025
    Article
  3. The Coding Logic of Interoception.Annual review of physiology · 2024
    Review
  4. Molecular profiling of COComparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2023
    Article
  5. Review
  6. Central respiratory chemoreception.Handbook of clinical neurology · 2022
    Review
  7. Article
  8. The role of TASK-2 channels in COAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020
    Article
  9. Review
  10. Breaking down COThe Journal of physiology · 2018
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher M GonçalvesDepartment of Physiology and Neurobiology, University of Connecticut, Storrs CT, USA.ORCID 0000-0002-9106-7870
Daniel K MulkeyDepartment of Physiology and Neurobiology, University of Connecticut, Storrs CT, USA.ORCID 0000-0002-7040-3927
University of Connecticut · US

Funding

Glial chemosensitivity: pH sensing and interactions with neuronal chemoreceptorsR01HL104101 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, OLSEN, MICHELLE L · 2010 to 2024
$5.5M
Role of KCNQ2 Channels in Control of BreathingR01HL137094 · NHLBI · UNIVERSITY OF CONNECTICUT STORRS · PI MULKEY, DANIEL K, TZINGOUNIS, ANASTASIOS · 2018 to 2025
$4.1M
NHLBI NIH HHS R01 HL104101NHLBI NIH HHS R01 HL137094
6 · The paper itself

Abstract

key pointsChanges in CO ABSTRACT: Central chemoreception is the mechanism by which the brain regulates breathing in response to changes in tissue CO

Indexed as

Action PotentialsAnimalsAnimals, NewbornAstrocytesBicarbonatesBuffersCarbon DioxideCell NucleusChemoreceptor CellsHydrogen-Ion ConcentrationNeuronsRatsRats, Sprague-DawleyRespiratory CenterBicarbonatesBuffersCarbon Dioxidebrain slicechemoreceptionHCO3pHipH-independent

Identifiers

PMID29873079
PMCPMC6117565
OpenAlexW2891621723

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.