ArticleMaxillofacial plastic and reconstructive surgery2018
The effects of proteins released from silk mat layers on macrophages.
Article in Maxillofacial plastic and reconstructive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Mimicking Design Scaffolds Based on Nonwoven Biological Materials of Silk Cocoon for Soft Tissue Engineering at the Bone Interfacial Area: Structure, Morphology, and Performance Evaluation Based on In Vitro Testing, and Identification of Applied Biomaterials.ACS applied bio materials · 2025Article
- Relevant Properties and Potential Applications of Sericin in Bone Regeneration.Current issues in molecular biology · 2023Review
- 4-Hexylresorcinol Treatment before Degumming Increases the β-Sheet Structure of Silk Sericin and BMP-2 Expression in RAW264.7 Cells.International journal of molecular sciences · 2022Article
- Pressure-driven spreadable deferoxamine-laden hydrogels for vascularized skin flaps.Biomaterials science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study was to evaluate the changes in gene expression after incubation of cells with proteins released from different silk mat layers.
methodsA silk cocoon from
resultsLayer 1 and 4 groups had higher protein concentrations compared to those in layer 2 and 3 groups. The genes associated with inflammation and angiogenesis showed significantly higher expression in layer 1 and 4 groups. The results of qRT-PCR were in agreement with those of the cDNA microarray analysis.
conclusionsThe silk mat from the middle portion of the silkworm cocoon yielded a lower protein release and caused an insignificant change in the expression of genes that are associated with inflammation and angiogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.