Evidence map›Paper›PMID 29872623›Full record

ArticleActa pharmaceutica Sinica. B2018

Surface modification of PGP for a neutrophil-nanoparticle co-vehicle to enhance the anti-depressant effect of baicalein.

Baoyu Chen, Man Luo, Jianming Liang, Chun Zhang, Caifang Gao, Jue Wang, Jianxin Wang, Yongji Li, Desheng Xu, Lina Liu and 3 more

Abstract read
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Baoyu ChenShanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Man LuoDepartment of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Jianming LiangDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Chun ZhangDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Caifang GaoDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Jue WangDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Jianxin WangDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Yongji LiDepartment of Pharmaceutics, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Desheng XuShanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lina LiuDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
Ning ZhangShanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Huijun ChenThe Second Hospital Affiliated Heilongjiang University of Traditional Chinese Medicine, Harbin 150001, China.
Jing QinDepartment of Pharmaceutics, School of Pharmacy, Fudan University; Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exploiting cells as vehicles combined with nanoparticles combined with therapy has attracted increasing attention in the world recently. Red blood cells, leukocytes and stem cells have been used for tumor immunotherapy, tissue regeneration and inflammatory disorders, and it is known that neutrophils can accumulate in brain lesions in many brain diseases including depression.

Indexed as

BaicaleinDepressionDual-brain targeting deliveryNeutrophilsOlfactory bulbectomy ratsPGP peptideSolid lipid nanoparticle

Identifiers

PMID29872623
PMCPMC5985696

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.