Evidence map›Paper›PMID 29872543›Full record

ArticleNPJ systems biology and applications2018

A data-driven, knowledge-based approach to biomarker discovery: application to circulating microRNA markers of colorectal cancer prognosis.

Fatemeh Vafaee, Connie Diakos, Michaela B Kirschner, Glen Reid, Michael Z Michael, Lisa G Horvath, Hamid Alinejad-Rokny, Zhangkai Jason Cheng, Zdenka Kuncic, Stephen Clarke

Abstract read
In one paragraph

Article in NPJ systems biology and applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Epigenetics, microRNA and Metabolic Syndrome: A Comprehensive Review.International journal of molecular sciences · 2021
    Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fatemeh Vafaee1School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2033 Australia.ORCID 0000-0002-7521-2417
Connie Diakos2Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065 Australia.
Michaela B Kirschner3Asbestos Diseases Research Institute, Hospital Road, Concord, NSW 2139 Australia.ORCID 0000-0001-7444-9829
Glen Reid3Asbestos Diseases Research Institute, Hospital Road, Concord, NSW 2139 Australia.
Michael Z Michael5Flinders Centre for Innovation in Cancer, Flinders Medical Centre, Flinders University, Adelaide, SA 5042 Australia.ORCID 0000-0001-5954-7105
Lisa G Horvath4Sydney Medical School, University of Sydney, Sydney, NSW 2050 Australia.
Hamid Alinejad-Rokny8University of New South Wales, Sydney, NSW 2052 Australia.
Zhangkai Jason Cheng9Charles Perkins Centre, University of Sydney, Sydney, NSW 2006 Australia.
Zdenka Kuncic9Charles Perkins Centre, University of Sydney, Sydney, NSW 2006 Australia.ORCID 0000-0001-6765-3215
Stephen Clarke2Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065 Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in high-throughput technologies have provided an unprecedented opportunity to identify molecular markers of disease processes. This plethora of complex-omics data has simultaneously complicated the problem of extracting meaningful molecular signatures and opened up new opportunities for more sophisticated integrative and holistic approaches. In this era, effective integration of

Identifiers

PMID29872543
PMCPMC5981448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.