ArticleOncotarget2018
Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.
Open access · diamondAbstract read
In one paragraph
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 118 citations in OpenAlex.
- Pooled it
- Integrating proteomics and metabolomics to reveal MAT2A for metabolic reprogramming in non-small cell lung cancer cells.iScience · 2026Article
- Targeting colorectal cancer and T‑cell metabolism for the treatment of colorectal cancer (Review).Oncology reports · 2026Review
- Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence.Biomarker research · 2026Review
- Article
- FASN Inhibition Enhances the Efficacy of Chemotherapy in Colorectal Cancer by Inhibiting the DNA Damage Response.Cancer research · 2026Article
- Mammarenaviruses depend on endogenous fatty acid synthesis in cell culture systems.Journal of lipid research · 2026Article
- Fatty acid metabolic reprogramming in the tumor microenvironment: Unraveling mechanisms and therapeutic prospects.Genes & diseases · 2026Review
- Targeting fatty acid metabolism for cancer therapy.Fundamental research · 2026Review
- Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapy.Annals of medicine · 2025Review
- Rewriting the MASLD-associated hepatocellular carcinoma script: Targeting epigenetics and metabolism.International journal of cancer · 2025Review
- Lipid metabolic reprogramming in colorectal cancer: Insights to mechanisms and therapeutics.World journal of gastrointestinal oncology · 2025Review
- Fatty acid binding protein 1 (FABP1) depletion promotes an oxidative metabolic shift in Caco-2 colorectal cancer cells.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2025Article
- Anoikis resistance in Cancer: Mechanisms, therapeutic strategies, potential targets, and models for enhanced understanding.Cancer letters · 2025Review
- Arid1a deficiency sensitises pancreatic cancer to fatty acid synthase inhibition.Clinical and translational medicine · 2025Article
- Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer.Redox biology · 2025Article
- Metabolic Reprogramming Shapes the Progression and Therapeutic Landscape of Ovarian Cancer.Cancer management and research · 2025Review
- Lipid metabolic reprogramming in colorectal cancer: mechanisms and therapeutic strategies.Frontiers in immunology · 2025Review
- Lung cancer and obesity: A contentious relationship (Review).Oncology reports · 2024Review
- Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment.International journal of molecular sciences · 2024Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 3 institutions in 1 country.
Yekaterina Y ZaytsevaDepartment of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, USA.
Piotr G RychahouMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Anh-Thu LeDepartment of Surgery, University of Kentucky, Lexington, KY, USA.
Timothy L ScottRC-SIRM, University of Kentucky, Lexington, KY, USA.
Robert M FlightRC-SIRM, University of Kentucky, Lexington, KY, USA.
Ji Tae KimMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Jennifer HarrisDepartment of Surgery, University of Kentucky, Lexington, KY, USA.
Jinpeng LiuMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Chi WangMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Andrew J MorrisCardiovascular Research, University of Kentucky, Lexington, KY, USA.
Theru A SivakumaranMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Teresa FanRC-SIRM, University of Kentucky, Lexington, KY, USA.
Hunter MoseleyRC-SIRM, University of Kentucky, Lexington, KY, USA.
Tianyan GaoMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Eun Y LeeDepartment of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, USA.
Heidi L WeissMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
Timothy S Heuer3-V Biosciences, Menlo Park, CA, USA.
George Kemble3-V Biosciences, Menlo Park, CA, USA.
Mark EversMarkey Cancer Center, University of Kentucky, Lexington, KY, USA.
University of Kentucky · USMarkey Cancer Center · USPacific Biosciences (United States) · US
Funding
University of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3MUniversity of Kentucky Center for Cancer MetabolismP20GM121327 · NIGMS · UNIVERSITY OF KENTUCKY · PI Binhua P Zhou · 2017 to 2026
$25.0MThe role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI ABDEL-LATIF, AHMED · 2012 to 2017
$13.7MSAMPLE COREU24DK097215 · NIDDK · UNIVERSITY OF KENTUCKY · PI FAN, TERESA WHEI-MEI, HIGASHI, RICHARD M · 2013 to 2017
$8.7MThe Role of PHLPP in Colon CancerR01CA133429 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI GAO, TIANYAN · 2009 to 2024
$5.6MMechanisms Regulating Neurotensin Secretion and FunctionR01DK112034 · NIDDK · UNIVERSITY OF KENTUCKY · PI EVERS, BERNARD MARK · 2017 to 2025
$4.9MAltered Lipid Metabolism as a Novel Target for Colon Cancer TreatmentR01CA208343 · NCI · UNIVERSITY OF KENTUCKY · PI EVERS, BERNARD MARK, GAO, TIANYAN · 2017 to 2021
$2.1MNovel pRNA Nanoparticle Delivery as Directed Therapy for Colorectal Cancer MetastasisR01CA195573 · NCI · UNIVERSITY OF KENTUCKY · PI EVERS, BERNARD MARK, GUO, PEIXUAN · 2015 to 2019
$1.8MTriple Quadrupole Mass Spectrometer SystemS10OD021753 · OD · UNIVERSITY OF KENTUCKY · PI MORRIS, ANDREW J · 2017 to 2017
$352kThe Role of Fatty Acid Synthase in Regulation of Cancer Cells Survival and Metastasis in Colorectal CancerK22CA197193 · NCI · UNIVERSITY OF KENTUCKY · PI ZAYTSEVA, YEKATERINA · 2016 to 2016
$158kLysophosphatidic acid and cardiovascular disease riskI01CX001550 · VA · VA MEDICAL CENTER - LEXINGTON, KY · PI MORRIS, ANDREW J · 2017 to 2021
–CSRD VA I01 CX001550NCI NIH HHS K22 CA197193NCI NIH HHS P30 CA177558NCI NIH HHS R01 CA133429NCI NIH HHS R01 CA195573NCI NIH HHS R01 CA208343NIDDK NIH HHS R01 DK112034NIDDK NIH HHS U24 DK097215NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P20 GM121327NIH HHS S10 OD021753
Abstract
Fatty Acid Synthase (FASN), a key enzyme of
Indexed as
colorectal cancerFASNlipogenesispatient-derived xenograftsTVB-3664
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.