Evidence map›Paper›PMID 29872502›Full record

ArticleOncotarget2018

Emilie M J van Brummelen, Marc C Huisman, Linda J de Wit-van der Veen, Tapan K Nayak, Marcel P M Stokkel, Emma R Mulder, Otto S Hoekstra, Danielle J Vugts, Guus A M S Van Dongen, Henk M Verheul and 5 more

Open access · diamondAbstract read
In one paragraph

Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Cergutuzumab Amunaleukin in Combination with Atezolizumab in Patients with Carcinoembryonic Antigen-Positive Advanced/Metastatic Solid Tumors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Non-specific irreversibleEJNMMI research · 2024
    Article
  14. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  15. Review
  16. Article
  17. Article
  18. Intratumorally anchored cytokine therapy.Expert opinion on drug delivery · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Emilie M J van BrummelenThe Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marc C HuismanVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Linda J de Wit-van der VeenThe Netherlands Cancer Institute, Amsterdam, The Netherlands.
Tapan K NayakRoche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Marcel P M StokkelThe Netherlands Cancer Institute, Amsterdam, The Netherlands.
Emma R MulderVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Otto S HoekstraVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Danielle J VugtsVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Guus A M S Van DongenVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Henk M VerheulVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Stefan EversRoche Pharma Research and Early Development, Roche Innovation Center, Zurich, Switzerland.
Jean J L TessierRoche Pharma Research and Early Development, Roche Innovation Center, Basel, Switzerland.
Jose SaroRoche Pharma Research and Early Development, Roche Innovation Center, Zurich, Switzerland.
Jan H M SchellensThe Netherlands Cancer Institute, Amsterdam, The Netherlands.
C Willemien Menke-van der Houven van OordtVU University Medical Center/Cancer Centre, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLRoche (Switzerland) · CHThe Netherlands Cancer Institute · NLCentre for Human Drug Research · NLPharmo Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cergutuzumab amunaleukin (CEA-IL2v) is an immunocytokine directed against carcinoembryonic antigen (CEA) containing an IL2v-moiety with abolished IL-2 receptor (IL-2R) α binding. We describe the biodistribution and tumor accumulation of

Indexed as

89Zrbiodistributionimmunocytokineimmuno-PETinterleukin-2

Identifiers

PMID29872502
PMCPMC5973872
OpenAlexW2887444888

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.