ArticleEuropean endocrinology2014
Interstitium versus Blood Equilibrium in Glucose Concentration and its Impact on Subcutaneous Continuous Glucose Monitoring Systems.
Article in European endocrinology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Subcutaneous glucose tracking during extreme perioperative perfusion stress: a prospective microdialysis study.Journal of clinical monitoring and computing · 2026Article
- Integrating Pharmacists into CGM-Enabled Digital Diabetes Care: Advancing Personalized and Data-Driven Management.Healthcare (Basel, Switzerland) · 2026Review
- Wearable devices for patient monitoring in the intensive care unit.Intensive care medicine experimental · 2025Review
- The Impact of Sex, Body Mass Index, Age, Exercise Type and Exercise Duration on Interstitial Glucose Levels during Exercise.Sensors (Basel, Switzerland) · 2023Article
- Monitoring of Diabetes Mellitus Using the Flash Glucose Monitoring System: The Owners' Point of View.Veterinary sciences · 2023Article
- Comparing the Rise in Glucose Concentration in Blood, Aqueous and Interstitial Fluid During a Glucose Tolerance Test.Translational vision science & technology · 2022Article
- Design of the micropump and mass-transfer compartment of a microfluidic system for regular nonenzymatic glucose measurement.Biotechnology reports (Amsterdam, Netherlands) · 2022Article
- Article
- Correlation between short- and mid-term hemoglobin A1c and glycemic control determined by continuous glucose monitoring.Diabetology & metabolic syndrome · 2021Article
- Accuracy of a flash glucose monitoring system in cats and determination of the time lag between blood glucose and interstitial glucose concentrations.Journal of veterinary internal medicine · 2021Article
- Sampling interstitial fluid from human skin using a microneedle patch.Science translational medicine · 2020Article
- Monitoring biomolecule concentrations in tissue using a wearable droplet microfluidic-based sensor.Nature communications · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between both interstitial and blood glucose remains a debated topic, on which there is still no consensus. The experimental evidence suggests that blood and interstitial fluid glucose levels are correlated by a kinetic equilibrium, which as a consequence has a time and magnitude gradient in glucose concentration between blood and interstitium. Furthermore, this equilibrium can be perturbed by several physiological effects (such as foreign body response, wound-healing effect, etc.), with a consequent reduction of interstitial fluid glucose versus blood glucose correlation. In the present study, the impact of operating in the interstitium on continuous glucose monitoring systems (CGMs) will be discussed in depth, both for the application of CGMs in the management of diabetes and in other critical areas, such as tight glycaemic control in critically ill patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.