Evidence map›Paper›PMID 29872426›Full record

ArticleFrontiers in microbiology2018

Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the

Fabio E Leal, Soraya Maria Menezes, Emanuela A S Costa, Phillip M Brailey, Lucio Gama, Aluisio C Segurado, Esper G Kallas, Douglas F Nixon, Tim Dierckx, Ricardo Khouri and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 18 citations in OpenAlex.

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  13. [Increased TRIM5 is associated with a poor prognosis and immune infiltration in glioma patients].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Fabio E LealOncovirology Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Soraya Maria MenezesDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Emanuela A S CostaDepartamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Phillip M BraileyOncovirology Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Lucio GamaDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Aluisio C SeguradoDepartamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Esper G KallasDepartamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Douglas F NixonOncovirology Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Tim DierckxDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Ricardo KhouriDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Jurgen VercauterenDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Bernardo Galvão-CastroEscola Bahiana de Medicina e Saúde Pública, Salvador-Bahia, Brazil.
Rui Andre Saraiva RaposoOncovirology Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil.
Johan Van WeyenberghDepartment of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven, Leuven, Belgium.
Instituto Nacional do Câncer · BRKU Leuven · BEUniversidade de São Paulo · BRRega Institute for Medical Research · BEEscola Bahiana de Medicina e Saúde Pública · BRGeorge Washington University · USJohns Hopkins University · US

Funding

SWG 2: Cure Research Scientific Working GroupP30AI117970 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI MICHAEL Ilya BUKRINSKY · 2015 to 2026
$29.6M
The District of Columbia Developmental Center for AIDS Research (DC D-CFAR)P30AI087714 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI GREENBERG, ALAN EDWARD · 2010 to 2014
$8.4M
NIAID NIH HHS P30 AI087714NIAID NIH HHS P30 AI117970
6 · The paper itself

Abstract

HTLV-1-Associated Myelopathy (HAM/TSP) is a progressive neuroinflammatory disorder for which no disease-modifying treatment exists. Modest clinical benefit from type I interferons (IFN-α/β) in HAM/TSP contrasts with its recently identified IFN-inducible gene signature. In addition, IFN-α treatment

Indexed as

evolutionHIVHTLV-1interferonmultiple sclerosisneuroinflammationretrovirustranscriptomics

Identifiers

PMID29872426
PMCPMC5972197
OpenAlexW2803745832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.