ArticleFrontiers in human neuroscience2018
Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients.
Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Genital-prioritized attentional bias in lifelong premature ejaculation: behavioral evidence from eye-tracking and machine learning.International journal of impotence research · 2026Article
- The role of acupuncture in treating premature ejaculation and its probable neurobiological mechanism.Basic and clinical andrology · 2024Review
- Altered regional brain activity and functional connectivity in primary intravaginal anejaculation patients revealed by resting-state fMRI.Asian journal of andrology · 2024Article
- Abnormal cortical surface-based spontaneous and functional connectivity in the whole brain in lifelong premature ejaculation patients.Asian journal of andrology · 2023Article
- Changes of insular function in lifelong premature ejaculation patients before and after SSRI administration.Psychopharmacology · 2022Article
- Functional Connectivity of Nucleus Accumbens Is Associated with Lifelong Premature Ejaculation in Male Adults : A Resting-state fMRI Study.Clinical neuroradiology · 2022Article
- Convergent and Divergent Structural Connectivity of Brain White Matter Network Between Patients With Erectile Dysfunction and Premature Ejaculation: A Graph Theory Analysis Study.Frontiers in neurology · 2022Article
- Potential biomarkers for distinguishing primary from acquired premature ejaculation: A diffusion tensor imaging based network study.Frontiers in neuroscience · 2022Article
- Smaller volume and altered functional connectivity of the amygdala in patients with lifelong premature ejaculation.European radiology · 2021Article
- Higher inter-hemispheric homotopic connectivity in lifelong premature ejaculation patients: a pilot resting-state fMRI study.Quantitative imaging in medicine and surgery · 2021Article
- Abnormal degree centrality in lifelong premature ejaculation patients: an fMRI study.Brain imaging and behavior · 2021Article
- Changes in the Amplitude of Low-Frequency Fluctuation in Patients With Lifelong Premature Ejaculation by Resting-State Functional MRI.Sexual medicine · 2021Article
- Reconfiguration of Dynamic Functional Connectivity States in Patients With Lifelong Premature Ejaculation.Frontiers in neuroscience · 2021Article
- Is Ejaculation Frequency in Men Related to General and Mental Health? Looking Back and Looking Forward.Frontiers in psychology · 2021Review
- Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study.Frontiers in neuroscience · 2021Article
- Male Ejaculatory Endophenotypes: Revealing Internal Inconsistencies of the Concept in Heterosexual Copulating Rats.Frontiers in behavioral neuroscience · 2020Article
- Abnormal Resting-State Functional Connectivity in the Whole Brain in Lifelong Premature Ejaculation Patients Based on Machine Learning Approach.Frontiers in neuroscience · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lifelong premature ejaculation (LPE) is a common male sexual dysfunction. Lack of active control for rapid ejaculation brought great distress to sexual harmony and even fertility. Previous neurophysiology studies revealed an ejaculation-related control mechanism in the brain. However, it remains unclear whether this inhibitory network is altered in LPE patients. The present study investigated the central inhibitory network function of LPE patients by using stop signal task (SST)-related functional magnetic resonance imaging (fMRI) and resting-state functional connectivity (FC) analysis. The results showed no difference in task-related behavioral performance or neural activation during response inhibition between LPE patients and controls. However, LPE patients showed a significantly different correlation pattern between the stop signal reaction time (SSRT) and left inferior frontal gyrus (IFG) activation during successful inhibition, in which a typical negative correlation between SSRT and the activation was completely disappeared in patients. In addition, using the left IFG as a seed, patients showed weaker FC between the seed and two areas (left dentate nucleus (DN) and right frontal pole) compared with controls. These data suggest that LPE patients have an abnormal brain control network, which may contribute to the reduced central control of rapid ejaculation. This study provides new insights into the neural mechanism of LPE involving the central inhibitory network, which may offer an underlying intervention target for future treatment.
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