Evidence map›Paper›PMID 29872340›Full record

ArticleCancer management and research2018

Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies.

Qingyi Jia, Xiaodan Li, Ying Liu, Ling Li, Joey Sw Kwong, Kaiyun Ren, Yong Jiang, Xin Sun, Haoming Tian, Sheyu Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Guideline
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  12. Hyperthyroidism in adolescents.Endocrine connections · 2021
    Review
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  16. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 3 countries.

Qingyi Jia *Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Xiaodan Li *Department of Gastroenterology, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Ying Liu *Department of Pediatrics, West China Second University Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Ling LiChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Joey Sw KwongChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Kaiyun RenDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Yong JiangDepartment of Pathology, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Xin SunChinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Haoming TianDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Sheyu LiDepartment of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD. MATERIALS AND

methodsWe searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. The last search was updated to January 23, 2018. All statistical tests were performed using Review Manager 5.3 and STATA version 12.0.

resultsEleven cohort studies involving 10,743 GD and 3,336 non-GD patients were included. The pooled prevalence of ITC was 7.0% (95% confidence interval [CI] 4.5-9.6), and was comparable in surgery-treated GD and non-GD hyperthyroid patients (GD vs non-GD: pooled odds ratio [OR], 1.0; 95% CI: 0.68-1.46;

conclusionOur study demonstrated that GD was not associated with increased risk of ITC in surgery-treated hyperthyroid patients.

Indexed as

autoimmune thyroid diseaseGraves’ diseasehyperthyroidismincidental thyroid carcinomameta-analysis

Identifiers

PMID29872340
PMCPMC5973324
OpenAlexW2804324712

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.