ArticleTherapeutics and clinical risk management2018
Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients.
Article in Therapeutics and clinical risk management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Lipid Metabolism, Body Composition, and Diet in Acne Vulgaris: A Narrative Review.Metabolites · 2026Review
- The effects of retinoic acid therapy on salivary and serum IL-1β, IL-8 and MCP-1 levels in periodontally healthy individuals: a prospective cohort study.Clinical oral investigations · 2025Observational
- The Impact of Isotretinoin on Lipid Profile: a Systematic Review.Annals of medicine and surgery (2012) · 2025Review
- Integrated plasma metabolomic and proteomic analysis uncover the effects and mechanisms of isotretinoin in severe acne.Frontiers in pharmacology · 2025Article
- Untargeted Lipidomics Analysis to Discover Lipid Profiles and Biomarkers of Rabbit Acne Model and Reveal Action Mechanism of Isotretinoin.Drug design, development and therapy · 2024Article
- Serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.Caspian journal of internal medicine · 2024Article
- Nontargeted metabolomics to characterize the effects of isotretinoin on skin metabolism in rabbit with acne.Frontiers in pharmacology · 2022Article
- Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?International journal of molecular sciences · 2021Review
- Isotretinoin Induced Hyperlipidemia and Impact of Leptin GenePharmacogenomics and personalized medicine · 2021Article
- The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.Dermatology research and practice · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIsotretinoin, a vitamin A-derived medication, is one of the effective treatments for severe acne. However, in a fraction of patients, this treatment causes significant adverse effects. Leptin is a pro-inflammatory cytokine that plays a role in apoptosis of adipose cells and sebaceous lipid metabolism. Thus, genetic polymorphisms in the leptin ( MATERIALS AND
methodsClinical parameters were obtained from 200 patients before and after isotretinoin treatment for acne. In addition, circulatory lipid profile and aspartate transaminase (AST) and alanine aminotransferase (ALT) enzymes from acne subjects before and 1 month after oral isotretinoin treatment were also measured.
resultsAn association between the rs7799039 polymorphism and the following lipid parameters: high-density lipoprotein (HDL) at baseline and after treatment, HDL % change, low-density lipoprotein % change and total cholesterol % change (
conclusionIn conclusion, rs7799039
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