Evidence map›Paper›PMID 29872295›Full record

ArticleInternational journal of nanomedicine2018

Antimicrobial peptide-loaded liquid crystalline precursor bioadhesive system for the prevention of dental caries.

Kelly Limi Aida, Paula Fernanda Kreling, Karina Sampaio Caiaffa, Giovana Maria Fioramonti Calixto, Marlus Chorilli, Denise Mp Spolidorio, Norival Alves Santos-Filho, Eduardo Maffud Cilli, Cristiane Duque

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Review
  8. Article
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  10. Article
  11. Review
  12. Nanotechnology in drug and gene delivery.Naunyn-Schmiedeberg's archives of pharmacology · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Nanoparticles in Dentistry: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  17. Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kelly Limi AidaDepartment of Pediatric Dentistry and Public Health, Araçatuba Dental School, Sao Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Paula Fernanda KrelingDepartment of Pediatric Dentistry and Public Health, Araçatuba Dental School, Sao Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Karina Sampaio CaiaffaDepartment of Endodontics, Araçatuba Dental School, Sao Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Giovana Maria Fioramonti CalixtoDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Marlus ChorilliDepartment of Drugs and Medicines, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Denise Mp SpolidorioDepartment of Physiology and Pathology, Araraquara Dental School, Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Norival Alves Santos-FilhoDepartment of Biochemistry and Chemical Technology, Institute of Chemistry, Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Eduardo Maffud CilliDepartment of Biochemistry and Chemical Technology, Institute of Chemistry, Sao Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Cristiane DuqueDepartment of Pediatric Dentistry and Public Health, Araçatuba Dental School, Sao Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Centro Universitário de Araraquara · BRCentro Universitario Toledo · BRAmerican Association of Endodontists · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnticaries agents must interfere with the adhesion of

methodsTo overcome the aforementioned disadvantage, this study developed and character-ized a drug delivery system and evaluated the cytotoxicity and effect against

resultsPLM, rheology, and in vitro bioadhesion tests showed that both viscosity and bioadhesion of LCS increased after it was diluted with artificial saliva. D1-23-loaded LCS system presented better activity against

conclusionD1-23-loaded LCS is a promising drug delivery system for the prevention of dental caries.

Indexed as

AcrylatesAnti-Bacterial AgentsAntimicrobial Cationic Peptidesbeta-DefensinsBiofilmsCell LineDental CariesDental CementsDrug Delivery SystemsEpithelial CellsHumansLiquid CrystalsMicrobial Sensitivity TestsStreptococcus mutansAcrylatesAnti-Bacterial AgentsAntimicrobial Cationic Peptidesbeta-Defensinscarbopol 971Pcarbopol 974P NFDental Cementsbiofilmdental cariesdrug delivery systempeptide fragmentsStreptococcus mutans

Identifiers

PMID29872295
PMCPMC5975612
OpenAlexW2804300277

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.