Evidence map›Paper›PMID 29872269›Full record

ArticleDrug design, development and therapy2018

Synthesis and evaluation of

Chi-Wei Chang, Chun-Nan Yeh, Yi-Hsiu Chung, Yong-Ren Chen, Shi-Wei Tien, Tsung-Wen Chen, Shiou-Shiow Farn, Ying-Cheng Huang, Chung-Shan Yu

Open access · goldAbstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. A comprehensive review ofMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  3. Review
  4. Cyclooxygenases as Potential PET Imaging Biomarkers to Explore Neuroinflammation in Dementia.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  5. Article
  6. Review
  7. DeuterationRSC advances · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chi-Wei Chang *Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
Chun-Nan Yeh *Department of Surgery, Liver Research Center, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
Yi-Hsiu Chung *Center for Advanced Molecular Imaging and Translation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Yong-Ren ChenDepartment of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan.
Shi-Wei TienDepartment of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan.
Tsung-Wen ChenDepartment of Surgery, Liver Research Center, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
Shiou-Shiow FarnDepartment of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan.
Ying-Cheng HuangDepartment of Neurosurgery, Chang-Gung Memorial Hospital at Linkou, Chang Gung University, Taoyuan, Taiwan.
Chung-Shan YuDepartment of Biomedical Engineering and Environmental Sciences, National Tsinghua University, Hsinchu, Taiwan.
National Tsing Hua University · TWLinkou Chang Gung Memorial Hospital · TWChang Gung Memorial Hospital · TWChang Gung University · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAn

methodsThe in vivo uptake of celecoxib was monitored with

resultsThe IC

conclusionThe inferior in vivo blocking results of 1.48±0.20 (T/N) and 1.18±0.22 (%ID/g) suggests that the nonspecificity is associated with the complex role of peroxidase or the binding to carbonic anhydrase.

Indexed as

AnimalsCelecoxibCholangiocarcinomaCyclooxygenase 2DihydroxyphenylalanineDisease Models, AnimalDose-Response Relationship, DrugMaleMiceMolecular StructurePositron-Emission TomographyRadiopharmaceuticalsRatsRats, Sprague-DawleyCelecoxibCyclooxygenase 2Dihydroxyphenylalaninefluorodopa F 18RadiopharmaceuticalsblockingcelecoxibfluorinationimagingNSAIDsPET

Identifiers

PMID29872269
PMCPMC5973465
OpenAlexW2804494927

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.