Evidence map›Paper›PMID 29872266›Full record

ArticleDrug design, development and therapy2018

In silico and in vivo characterization of cabralealactone, solasodin and salvadorin in a rat model: potential anti-inflammatory agents.

Arif Malik, Mahwish Arooj, Tariq Tahir Butt, Sara Zahid, Fatima Zahid, Tassadaq Hussain Jafar, Sulayman Waquar, Siew Hua Gan, Sarfraz Ahmad, Muhammad Usman Mirza

Abstract read
In one paragraph

Article in Drug design, development and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Wound Healing Potential and In Silico Appraisal ofBioMed research international · 2022
    Article
  7. Aminodextran Coated CoFeNanomaterials (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arif MalikInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Mahwish AroojUniversity College of Medicine and Dentistry (UCMD), University of Lahore, Lahore, Pakistan.
Tariq Tahir ButtKhawaja Muhammad Safdar Medical College, Sialkot, Pakistan.
Sara ZahidFaculty of Pharmacy, University of Lahore, Lahore, Pakistan.
Fatima ZahidInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Tassadaq Hussain JafarInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Sulayman WaquarInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Siew Hua GanSchool of Pharmacy, Monash University Malaysia, Subang Jaya, Malaysia.
Sarfraz AhmadInstitute of Molecular Biology and Biotechnology (IMBB), University of Lahore, Lahore, Pakistan.
Muhammad Usman MirzaDepartment of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Medicinal Chemistry, University of Leuven, Leuven, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study investigates the hepato- and DNA-protective effects of standardized extracts of MATERIALS AND

methodsHepatotoxicity was induced with intraperitoneal injection of carbon tetrachloride (CCl

resultsHistopathological findings of the liver sections from the rat group which received CCl

conclusionCabralealactone, solasodin, and salvadorin confer some hepatoprotective and DNA-damage protective effects against CCl

Indexed as

Disease Models, AnimalAnimalsAnti-Inflammatory AgentsCarbon TetrachlorideCoumarinsCyclooxygenase 2DNAInjections, IntraperitonealLactonesLiverMolecular Docking SimulationNaphthalenesOxidative StressRatsSolanaceous AlkaloidsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsCarbon TetrachlorideCoumarinsCyclooxygenase 2DNALactonesNaphthalenessalvadorinSolanaceous AlkaloidssolasodineTumor Necrosis Factor-alphaanti-inflammatoryantioxidantcabralealactoneCOX-2 inhibitorsalvadorinsolasodin

Identifiers

PMID29872266
PMCPMC5973396

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.