Evidence map›Paper›PMID 29872218›Full record

ArticleNature communications2018

Mapping higher-order relations between brain structure and function with embedded vector representations of connectomes.

Gideon Rosenthal, František Váša, Alessandra Griffa, Patric Hagmann, Enrico Amico, Joaquín Goñi, Galia Avidan, Olaf Sporns

Abstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

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  10. Fully Hyperbolic Neural Networks: A Novel Approach to Studying Aging Trajectories.IEEE journal of biomedical and health informatics · 2025
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  11. Article
  12. Article
  13. Neural network embedding of functional microconnectome.Network neuroscience (Cambridge, Mass.) · 2025
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gideon RosenthalDepartment of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, P.O.B. 653, 8410501, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0002-9783-0590
František VášaBrain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
Alessandra GriffaDepartment of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1011, Lausanne, Switzerland.
Patric HagmannDepartment of Radiology, Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL), 1011, Lausanne, Switzerland.
Enrico AmicoSchool of Industrial Engineering, Purdue University, West-Lafayette, 47907, IN, USA.
Joaquín GoñiSchool of Industrial Engineering, Purdue University, West-Lafayette, 47907, IN, USA.
Galia AvidanDepartment of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, P.O.B. 653, 8410501, Beer-Sheva, Israel.
Olaf SpornsDepartment of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA. osporns@indiana.edu.

Funding

Statistical models for multi-modal brain imaging studies of HIV-associated cognitive declineR01MH108467 · NIMH · INDIANA UNIVERSITY INDIANAPOLIS · PI HAREZLAK, JAROSLAW · 2015 to 2019
$2.0M
Integrative Bioinformatics Approaches to Human Brain Genomics and ConnectomicsR01EB022574 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI SHEN, LI · 2016 to 2019
$1.9M
CRCNS: Linking connectomic and large-Scale Dynamics of the Human BrainR01AT009036 · NCCIH · TRUSTEES OF INDIANA UNIVERSITY · PI SPORNS, OLAF · 2015 to 2017
$443k
NCCIH NIH HHS R01 AT009036NIBIB NIH HHS R01 EB022574NIMH NIH HHS R01 MH108467
6 · The paper itself

Abstract

Connectomics generates comprehensive maps of brain networks, represented as nodes and their pairwise connections. The functional roles of nodes are defined by their direct and indirect connectivity with the rest of the network. However, the network context is not directly accessible at the level of individual nodes. Similar problems in language processing have been addressed with algorithms such as word2vec that create embeddings of words and their relations in a meaningful low-dimensional vector space. Here we apply this approach to create embedded vector representations of brain networks or connectome embeddings (CE). CE can characterize correspondence relations among brain regions, and can be used to infer links that are lacking from the original structural diffusion imaging, e.g., inter-hemispheric homotopic connections. Moreover, we construct predictive deep models of functional and structural connectivity, and simulate network-wide lesion effects using the face processing system as our application domain. We suggest that CE offers a novel approach to revealing relations between connectome structure and function.

Indexed as

BrainComputer SimulationConnectomeDiffusion Tensor ImagingHumansImage Processing, Computer-AssistedModels, NeurologicalNerve NetRotation

Identifiers

PMID29872218
PMCPMC5988787

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.