Evidence map›Paper›PMID 29872128›Full record

ArticleBone marrow transplantation2018

EBMT-NIH-CIBMTR Task Force position statement on standardized terminology & guidance for graft-versus-host disease assessment.

Helene M Schoemans, Stephanie J Lee, James L Ferrara, Daniel Wolff, John E Levine, Kirk R Schultz, Bronwen E Shaw, Mary E Flowers, Tapani Ruutu, Hildegard Greinix and 5 more

Abstract readConsensus Statement
In one paragraph

Article in Bone marrow transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 263 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
263citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

263 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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203 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Helene M SchoemansDepartment of Hematology, University Hospital Leuven and KU Leuven, Leuven, Belgium. helene.schoemans@uzleuven.be.ORCID http://orcid.org/0000-0002-7568-8239
Stephanie J LeeClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
James L FerraraDivision of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel WolffDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
John E LevineDivision of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Kirk R SchultzMichael Cuccione Childhood Cancer Research Program, BC Children's Hospital, UBC, Vancouver, Canada.ORCID http://orcid.org/0000-0002-0001-6438
Bronwen E ShawCenter for International Blood and Bone Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA.
Mary E FlowersClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tapani RuutuClinical Research Institute, Helsinki University Hospital, Helsinki, Finland.
Hildegard GreinixDivision of Hematology, Medical University of Graz, Graz, Austria.
Ernst HollerDepartment of Internal Medicine III, University Hospital Regensburg, Regensburg, Germany.
Grzegorz BasakDepartment of Hematology, Oncology and Internal Medicine, Medical University of Warsaw, Warszawa, Poland.ORCID http://orcid.org/0000-0003-3858-8180
Rafael F DuarteHospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Steven Z PavleticCenter for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
EBMT (European Society for Blood and Marrow Transplantation) Transplant Complications Working Party and the “EBMT−NIH (National Institutes of Health)−CIBMTR (Center for International Blood and Marrow Transplant Research) GvHD Task Force”

Funding

NIH Chronic GVHD Study GroupZIABC011743 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI PAVLETIC, STEVEN · 2016 to 2025
$10.2M
Intramural NIH HHS Z99 CA999999Intramural NIH HHS ZIA BC011743
6 · The paper itself

Abstract

Several international recommendations address the assessment of graft-versus-host disease (GvHD) after hematopoietic cell transplantation (HCT). This position statement by GvHD experts from the European Society for Blood and Marrow Transplantation (EBMT), the National Institutes of Health (NIH) and the Center for International Blood and Marrow Transplant Research (CIBMTR) reviews the existing guidelines for both acute and chronic GvHD, addresses potential confusions that arise in daily practice and proposes consensus definitions for many key terms. We provide a historical perspective on the currently available guidelines and recommend the Mount Sinai Acute GvHD International Consortium (MAGIC) criteria for acute GvHD and the NIH 2014 criteria for chronic GvHD as the most comprehensive and detailed criteria available. This statement also offers practical guidance for the implementation of these recommendations and a set of consensus definitions for commonly used GvHD terms in order to facilitate future clinical and translational research. To assist the dissemination of these recommendations, a web-application based on this position statement is available ( https://www.uzleuven.be/egvhd ). We believe that adherence to a common set of GvHD assessment criteria is vitally important to improve the quality of data, compare results of retrospective studies and prospective clinical trials, and make therapeutic recommendations based on quality evidence.

Indexed as

Graft vs Host DiseaseHumansNational Institutes of Health (U.S.)Terminology as TopicUnited States

Identifiers

PMID29872128
PMCPMC6786777

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.