Evidence map›Paper›PMID 29872111›Full record

ArticleJournal of human genetics2018

Association between the FGFR1 rs13317 single nucleotide polymorphism and orbitale-nasion depth based on cephalometric images.

Mohamed Adel, Tetsutaro Yamaguchi, Daisuke Tomita, Yong-Il Kim, Masahiro Takahashi, Takatoshi Nakawaki, Yu Hikita, Shugo Haga, Mohamed Nadim, Akira Kawaguchi and 7 more

Abstract read
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In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Mohamed AdelDepartment of Orthodontics, Showa University, Tokyo, Japan.
Tetsutaro YamaguchiDepartment of Orthodontics, Showa University, Tokyo, Japan. tyamaguchi@dent.showa-u.ac.jp.
Daisuke TomitaDepartment of Orthodontics, Showa University, Tokyo, Japan.
Yong-Il KimDepartment of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, South Korea.
Masahiro TakahashiDepartment of Orthodontics, Showa University, Tokyo, Japan.
Takatoshi NakawakiDepartment of Orthodontics, Showa University, Tokyo, Japan.
Yu HikitaDepartment of Orthodontics, Showa University, Tokyo, Japan.
Shugo HagaDepartment of Orthodontics, Showa University, Tokyo, Japan.
Mohamed NadimDepartment of Orthodontics, Suez Canal University, Ismailia, Egypt.
Akira KawaguchiDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Mutsumi IsaDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Walid El-KenanyDepartment of Orthodontics, Alexandria University, Alexandria, Egypt.
Abbadi A El-KadiDepartment of Orthodontics, Suez Canal University, Ismailia, Egypt.
Soo-Byung ParkDepartment of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan, South Korea.
Hajime IshidaDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Koutaro MakiDepartment of Orthodontics, Showa University, Tokyo, Japan.
Ryosuke KimuraDepartment of Human Biology and Anatomy, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. rkimura@med.u-ryukyu.ac.jp.
Showa University · JPUniversity of the Ryukyus · JPPusan National University Dental Hospital · KRSuez Canal University · EGAlexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fibroblast growth factor receptor 1 (FGFR1) gene plays an important role in craniofacial morphogenesis. In our previous study, an association between FGFR1 single nucleotide polymorphisms (SNPs) and craniofacial morphology was demonstrated in Japanese and Korean subjects. The present study aimed to evaluate the relationship between a common FGFR1 SNP (rs13317) with craniofacial morphology, increasing the number of measurements and examining Egyptian subjects (n = 191) in addition to the Japanese (n = 211) and Korean (n = 226) subjects. Genotyping for rs13317 was performed using the TaqMan assay, and its associations with 81 craniofacial measurements derived from lateral and posteroanterior cephalograms were analyzed by multiple regression analysis controlling sex and facial size. The results from each of the populations were then statistically combined. In the Egyptian subjects, rs13317 was significantly associated with the nasion-orbitale depth (P = 0.00040), and a suggestive association was also observed in the Japanese (P = 0.037) and Korean subjects (P = 0.045). The combined analysis revealed that only the nasion-orbitale depth showed a significant association (P = 0.000062) and that several measurements showed a suggestive association. Our results strongly indicate that rs13317 is associated with a smaller depth between the nasion and orbitale, representing a relative protrusion of the cheekbones and retrusion of the nasal root. A similar characteristic is also observed in individuals with Pfeiffer syndrome, which is caused by a dysfunctional FGFR1 mutation.

Indexed as

CephalometryGenetic Association StudiesImage Processing, Computer-AssistedAdolescentAdultAnatomic LandmarksFaceFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideReceptor, Fibroblast Growth Factor, Type 1Regression AnalysisSkullYoung AdultReceptor, Fibroblast Growth Factor, Type 1

Identifiers

PMID29872111
OpenAlexW2807541693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.