Evidence map›Paper›PMID 29872091›Full record

ArticleScientific reports2018

Screening and characterisation of sex differentiation-related long non-coding RNAs in Chinese soft-shell turtle (Pelodiscus sinensis).

Jun Zhang, Peng Yu, Qinyan Zhou, Xilei Li, Shuquan Ding, Shiping Su, Xiaohua Zhang, Xiaoli Yang, Weishang Zhou, Quan Wan and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Epigenetic Regulation and Environmental Sex Determination in Cichlid Fishes.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2021
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jun ZhangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Peng YuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Qinyan ZhouCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Xilei LiCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Shuquan DingCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Shiping SuCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Xiaohua ZhangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Xiaoli YangCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Weishang ZhouCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China.
Quan WanCollege of Animal Science and Technology, Anhui Agricultural University, Hefei, 230036, China. ahwanquan@163.com.
Jian-Fang GuiState Key laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, China. jfgui@ihb.ac.cn.
Anhui Agricultural University · CNInstitute of Hydrobiology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) perform distinct functions in various biological processes in mammals, including sex differentiation. However, the roles of lncRNAs in other vertebrates, especially in the Chinese soft-shell turtle (Pelodiscus sinensis), remain to be clarified. In this study, we performed genome-wide analysis of the lncRNA expression profiles in gonad tissues and screened numerous sex-specific lncRNAs in the Chinese soft-shell turtle. Of the 363,310,650 clean reads obtained, 5,994 sequences were typed as lncRNAs, of which 4,463 were novel. A selection of sex-specific lncRNAs (♀ 932, ♂ 449) from female ovaries and male testis were shown to act on target genes in cis and in trans, and most were involved in gonad differentiation based on Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Furthermore, interactions among the differentially expressed lncRNA-mRNAs and protein coding genes were identified by construction of correlation networks. Overall, our systematic analysis of lncRNA expression profiles in gonad tissues revealed numerous sex-specific lncRNAs in P. sinensis. Thereby, these findings provide new insights into the function of lncRNAs in sex differentiation and highlight a group of candidate lncRNAs for future studies.

Indexed as

Sex DifferentiationAnimalsChinaFemaleGene Expression ProfilingGenome-Wide Association StudyGonadsMaleRNA, Long NoncodingTurtlesRNA, Long Noncoding

Identifiers

PMID29872091
PMCPMC5988831
OpenAlexW2806258193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.