Evidence map›Paper›PMID 29872078›Full record

ArticleEmerging microbes & infections2018

Have compensatory mutations facilitated the current epidemic of multidrug-resistant tuberculosis?

Qingyun Liu, Tianyu Zuo, Peng Xu, Qi Jiang, Jie Wu, Mingyu Gan, Chongguang Yang, Ravi Prakash, Guofeng Zhu, Howard E Takiff and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Emerging microbes & infections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
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  11. Review
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  14. Genomic Characterization of Drug-ResistantAntibiotics (Basel, Switzerland) · 2023
    Article
  15. Article
  16. Article
  17. Article
  18. Novel and reported compensatory mutations inFrontiers in microbiology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qingyun LiuKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Tianyu ZuoKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Peng XuKey Laboratory of Characteristic Infectious Disease & Bio-safety Development of Guizhou Province Education Department, Zunyi Medical University, Zunyi, Guizhou, China.
Qi JiangKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-3872-6312
Jie WuShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Mingyu GanKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Chongguang YangDepartment of Epidemiology of Microbial Diseases, School of Public Health, Yale University, New Haven, CT, USA.
Ravi PrakashKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Guofeng ZhuShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Howard E TakiffUnité de Génétique Mycobacterienne, Institut Pasteur, Paris, France.
Qian GaoKey Laboratory of Medical Molecular Virology at the School of Basic Medical Sciences, Shanghai Medical College, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. qgao99@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compensatory mutations have been suggested to promote multidrug-resistant tuberculosis (MDR-TB) transmission, but their role in facilitating the recent transmission of MDR-TB is unclear. To investigate the epidemiological significance of compensatory mutations, we analyzed a four-year population-based collection of MDR-TB strains from Shanghai (the most populous city in China) and 1346 published global MDR-TB strains. We report that MDR-TB strains with compensatory mutations in the rpoA, rpoB, or rpoC genes were neither more frequently clustered nor found in larger clusters than those without compensatory mutations. Our results suggest that compensatory mutations are not a major contributor to the current epidemic of MDR-TB.

Indexed as

Antitubercular AgentsBacterial ProteinsChinaDNA-Directed RNA PolymerasesDrug Resistance, BacterialHumansMicrobial Sensitivity TestsMutationMycobacterium tuberculosisPhylogenyTuberculosis, Multidrug-ResistantAntitubercular AgentsBacterial ProteinsDNA-Directed RNA PolymerasesrpoB protein, Mycobacterium tuberculosis

Identifiers

PMID29872078
PMCPMC5988693

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.