ArticleProceedings of the National Academy of Sciences of the United States of America2018
Individuality and slow dynamics in bacterial growth homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Emergent Homeostasis and Degeneracy From Multi-Dimensional Attractors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Gene expression cycles drive non-exponential bacterial growth.Physical review research · 2025Article
- Coupling Bacterial Cell Size Regulation with Clonal Proliferation Dynamics Reveals Cell Division Based on Surface Area.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary Advantage of Cell Size Control.Physical review letters · 2025Article
- Single-cell data reveal heterogeneity of investment in ribosomes across a bacterial population.Nature communications · 2025Article
- Article
- The Brain's Best Kept Secret Is Its Degenerate Structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Nonlethal deleterious mutation-induced stress accelerates bacterial aging.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Chaos in a bacterial stress response.Current biology : CB · 2023Article
- Bacterial cell-size changes resulting from altering the relative expression of Min proteins.Nature communications · 2023Article
- Super-exponential growth and stochastic size dynamics in rod-like bacteria.Biophysical journal · 2023Article
- Evolutionary scaling of maximum growth rate with organism size.Scientific reports · 2022Article
- Article
- Optimization and Fabrication of Multi-Level Microchannels for Long-Term Imaging of Bacterial Growth and Expansion.Micromachines · 2022Article
- Multiple timescales in bacterial growth homeostasis.iScience · 2022Article
- Roadmap on biology in time varying environments.Physical biology · 2021Review
- Article
- Bacterial cell proliferation: from molecules to cells.FEMS microbiology reviews · 2021Review
- Cell Cycle Heritability and Localization Phase Transition in Growing Populations.Physical review letters · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial growth and division are fundamental processes relevant to many areas of life science. Of particular interest are homeostasis mechanisms, which buffer growth and division from accumulating fluctuations over multiple cycles. These mechanisms operate within single cells, possibly extending over several division cycles. However, all experimental studies to date have relied on measurements pooled from many distinct cells. Here, we disentangle long-term measured traces of individual cells from one another, revealing subtle differences between temporal and pooled statistics. By analyzing correlations along up to hundreds of generations, we find that the parameter describing effective cell size homeostasis strength varies significantly among cells. At the same time, we find an invariant cell size, which acts as an attractor to all individual traces, albeit with different effective attractive forces. Despite the common attractor, each cell maintains a distinct average size over its finite lifetime with suppressed temporal fluctuations around it, and equilibration to the global average size is surprisingly slow ([Formula: see text] cell cycles). To show a possible source of variable homeostasis strength, we construct a mathematical model relying on intracellular interactions, which integrates measured properties of cell size with those of highly expressed proteins. Effective homeostasis strength is then influenced by interactions and by noise levels and generally varies among cells. A predictable and measurable consequence of variable homeostasis strength appears as distinct oscillatory patterns in cell size and protein content over many generations. We discuss implications of our results to understanding mechanisms controlling division in single cells and their characteristic timescales.
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