Evidence map›Paper›PMID 29871946›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source.

Jason M Cole, Daniel R Symes, Nelson C Lopes, Jonathan C Wood, Kristjan Poder, Saleh Alatabi, Stanley W Botchway, Peta S Foster, Sarah Gratton, Sara Johnson and 17 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  8. Article
  9. Mouse embryo phenotyping using X-ray microCT.Frontiers in cell and developmental biology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Jason M ColeThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.ORCID 0000-0001-6558-0788
Daniel R SymesCentral Laser Facility, Science and Technology Facilities Council (STFC) Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, United Kingdom; dan.symes@stfc.ac.uk.
Nelson C LopesThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Jonathan C WoodThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Kristjan PoderThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Saleh AlatabiThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Stanley W BotchwayCentral Laser Facility, Science and Technology Facilities Council (STFC) Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, United Kingdom.
Peta S FosterCentral Laser Facility, Science and Technology Facilities Council (STFC) Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, United Kingdom.
Sarah GrattonCentral Laser Facility, Science and Technology Facilities Council (STFC) Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, United Kingdom.
Sara JohnsonThe Mary Lyon Centre, MRC Harwell Institute, Harwell OX11 0RD, United Kingdom.
Christos KamperidisThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Olena KononenkoLinear Accelerator Technologies, Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany.
Michael De LazzariCancer Research UK/Medical Research Council (CRUK/MRC) Oxford Institute for Radiation Research, Gray Laboratories, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Charlotte A J PalmerLinear Accelerator Technologies, Deutsches Elektronen-Synchrotron (DESY), 22607 Hamburg, Germany.
Dean RusbyCentral Laser Facility, Science and Technology Facilities Council (STFC) Rutherford Appleton Laboratory, Chilton, Didcot OX11 0QX, United Kingdom.
Jeremy SandersonMedical Research Council (MRC) Harwell Institute, Harwell OX11 0RD, United Kingdom.
Michael SandholzerMedical Research Council (MRC) Harwell Institute, Harwell OX11 0RD, United Kingdom.
Gianluca SarriSchool of Mathematics and Physics, Queen's University, Belfast BT7 1NN, United Kingdom.
Zsombor Szoke-KovacsThe Mary Lyon Centre, MRC Harwell Institute, Harwell OX11 0RD, United Kingdom.
Lydia TeboulThe Mary Lyon Centre, MRC Harwell Institute, Harwell OX11 0RD, United Kingdom.
James M ThompsonCancer Research UK/Medical Research Council (CRUK/MRC) Oxford Institute for Radiation Research, Gray Laboratories, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Jonathan R WarwickSchool of Mathematics and Physics, Queen's University, Belfast BT7 1NN, United Kingdom.
Henrik WesterbergMedical Research Council (MRC) Harwell Institute, Harwell OX11 0RD, United Kingdom.
Mark A HillCancer Research UK/Medical Research Council (CRUK/MRC) Oxford Institute for Radiation Research, Gray Laboratories, University of Oxford, Oxford OX3 7DQ, United Kingdom.
Dominic P NorrisMedical Research Council (MRC) Harwell Institute, Harwell OX11 0RD, United Kingdom.
Stuart P D ManglesThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.
Zulfikar NajmudinThe John Adams Institute for Accelerator Science, Blackett Laboratory, Imperial College London, London SW7 2AZ, United Kingdom.

Funding

CRSPR II Supplement: Consortium for the production and cryopreservation of knockout miceU42OD011174 · OD · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2012 to 2015
$17.7M
Medical Research Council 53658Medical Research Council MC-PC-12004Medical Research Council MC_PC_12004Medical Research Council MC_U142670370Medical Research Council MC_U142760473Medical Research Council MC_UP_1502/1NIH HHS U42 OD011174
6 · The paper itself

Abstract

In the field of X-ray microcomputed tomography (μCT) there is a growing need to reduce acquisition times at high spatial resolution (approximate micrometers) to facilitate in vivo and high-throughput operations. The state of the art represented by synchrotron light sources is not practical for certain applications, and therefore the development of high-brightness laboratory-scale sources is crucial. We present here imaging of a fixed embryonic mouse sample using a compact laser-plasma-based X-ray light source and compare the results to images obtained using a commercial X-ray μCT scanner. The radiation is generated by the betatron motion of electrons inside a dilute and transient plasma, which circumvents the flux limitations imposed by the solid or liquid anodes used in conventional electron-impact X-ray tubes. This X-ray source is pulsed (duration <30 fs), bright (>10

Indexed as

AnimalsEquipment DesignLasersLightMiceParticle AcceleratorsPhotonsRadiographyScattering, RadiationX-Ray MicrotomographyX-Rayslaser–plasma accelerationmicrocomputed tomographyX-ray imaging

Identifiers

PMID29871946
PMCPMC6016801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.