Evidence map›Paper›PMID 29871905›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival.

Vivek Subbiah, Salah-Eddine Lamhamedi-Cherradi, Branko Cuglievan, Brian A Menegaz, Pamela Camacho, Winston Huh, Vandhana Ramamoorthy, Pete M Anderson, Raphael E Pollock, Dina C Lev and 10 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07695311 (Precision Analysis of Fusion Genes in Ewing Sarcoma), which is not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07695311 phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Precision Analysis of Fusion Genes in Ewing Sarcoma (ES) and Desmoplastic Small Round Cell Tumor (DSRCT), Then EWSR1 (Ewing Sarcoma Gene Breakpoint Region 1 Gene) Immunotherapy Without or With Anti-CTLA-4 (Botensilimab) and Anti-PD1 (Balstilimab)

TypeinterventionalSponsorRabi HannaRan2026 to 2030Enrolled24ConditionsEwing Sarcoma, Desmoplastic Small Round Cell TumorArmsEWSR1 immunotherapy, Botensilimab, Balstilimab
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. Review
  7. Article
  8. Article
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  10. Review
  11. Desmoplastic small round cell tumor: an update of current management practices.Journal of the Egyptian National Cancer Institute · 2025
    Review
  12. Article
  13. Article
  14. Emerging round cell sarcomas in children.Virchows Archiv : an international journal of pathology · 2025
    Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Vivek Subbiah *Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. jaludwig@mdanderson.org vsubbiah@mdanderson.org.
Salah-Eddine Lamhamedi-Cherradi *Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Branko CuglievanDivision of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Brian A MenegazDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Pamela CamachoDivision of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Winston HuhDivision of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Vandhana RamamoorthyDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Pete M AndersonDepartment of Pediatric Hematology/Oncology/BMT, Cleveland Clinic Foundation, Cleveland, Ohio.
Raphael E PollockDivision of Surgical Oncology, Ohio State University, Columbus, Ohio.
Dina C LevDivision of Surgical Oncology, Ohio State University, Columbus, Ohio.
Wei QiaoDivision of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mary Frances McAleerDivision of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Robert S BenjaminDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-2589-5870
Shreyaskumar PatelDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Cynthia E HerzogDivision of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-2645-4495
Najat C DawDivision of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Barry W FeigDivision of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Alexander J LazarDivision of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-6395-4499
Andrea Hayes-JordanDivision of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Joseph A LudwigDivision of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas. jaludwig@mdanderson.org vsubbiah@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USOhio State University Hospital · USCleveland Clinic · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Three-dimensional Model of Human Ewing SarcomaR01CA180279 · NCI · RICE UNIVERSITY · PI KASPER, FRED KURTIS, LUDWIG, JOSEPH A · 2014 to 2018
$1.8M
NCI NIH HHS L30 CA130659NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA180279
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cytoreduction Surgical ProceduresAdultCombined Modality TherapyDesmoplastic Small Round Cell TumorDisease-Free SurvivalFemaleHumansMaleRNA-Binding Protein EWSSarcoma, EwingYoung AdultEWSR1 protein, humanRNA-Binding Protein EWS

Identifiers

PMID29871905
PMCPMC6168359
OpenAlexW2807286649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.