Evidence map›Paper›PMID 29871865›Full record

ArticleDisease models & mechanisms2018

A novel rabbit model of Duchenne muscular dystrophy generated by CRISPR/Cas9.

Tingting Sui, Yeh Siang Lau, Di Liu, Tingjun Liu, Li Xu, Yandi Gao, Liangxue Lai, Zhanjun Li, Renzhi Han

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 87 citations in OpenAlex.

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  18. Dystrophin (International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Tingting SuiJilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, 130062, China.
Yeh Siang LauDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, US.
Di LiuJilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, 130062, China.
Tingjun LiuJilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, 130062, China.
Li XuDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, US.
Yandi GaoDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, US.
Liangxue LaiJilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, 130062, China lai_liangxue@gibh.ac.cn lizj_1998@jlu.edu.cn renzhi.han@osumc.edu.ORCID 0000-0003-4628-7513
Zhanjun LiJilin Provincial Key Laboratory of Animal Embryo Engineering, Jilin University, Changchun, 130062, China lai_liangxue@gibh.ac.cn lizj_1998@jlu.edu.cn renzhi.han@osumc.edu.ORCID 0000-0001-6914-8589
Renzhi HanDepartment of Surgery, Davis Heart and Lung Research Institute, Biomedical Sciences Graduate Program, Biophysics Graduate Program, The Ohio State University Wexner Medical Center, Columbus, OH 43210, US lai_liangxue@gibh.ac.cn lizj_1998@jlu.edu.cn renzhi.han@osumc.edu.ORCID 0000-0002-8202-9186
Jilin University · CNThe Ohio State University Wexner Medical Center · US

Funding

Molecular and cellular functions of Ano5 in heartR01HL116546 · NHLBI · OHIO STATE UNIVERSITY · PI HAN, RENZHI · 2013 to 2022
$4.4M
Mechanisms of Muscle Inflammation in Muscular DystrophyR01AR064241 · NIAMS · OHIO STATE UNIVERSITY · PI HAN, RENZHI · 2013 to 2017
$1.5M
NHLBI NIH HHS R01 HL116546NIAMS NIH HHS R01 AR064241
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disorder caused by mutations in the dystrophin gene, with an incidence of 1 in 3500 in new male births.

Indexed as

Clustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsAnimalsAnimals, Genetically ModifiedCardiomyopathiesCreatine Kinase, MM FormCRISPR-Associated Protein 9Disease Models, AnimalDisease ProgressionDystrophinFibrosisGene EditingGenetic Predisposition to DiseaseMuscle, SkeletalMuscular Dystrophy, DuchenneMyocardial ContractionCreatine Kinase, MM FormCRISPR-Associated Protein 9DystrophinCardiomyopathyCRISPRDystrophinGene editingMuscular dystrophyRabbit

Identifiers

PMID29871865
PMCPMC6031364
OpenAlexW2805427604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.