Evidence map›Paper›PMID 29871793›Full record

ArticleFertility and sterility2018

Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies.

Brianna M Lyttle Schumacher, Anne Marie Z Jukic, Anne Z Steiner

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Fertility and sterility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05969574 (Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study), which is not on this map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05969574 recruitingnot on this mapstarted 2023, after this paper: background citation

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study

TypeobservationalSponsorART Fertility Clinics LLCRan2023 to 2026Enrolled2,059ConditionsInfertility, Female, Miscarriage, Miscarriage, Recurrent, IVFArmsTransvaginal ultrasound, Blood test AMH
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Brianna M Lyttle SchumacherDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina. Electronic address: blyttle@med.unc.edu.
Anne Marie Z JukicYale School of Public Health, New Haven, Connecticut.
Anne Z SteinerDepartment of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina.
University of North Carolina at Chapel Hill · USYale New Haven Health System · US

Funding

Biomarkers of InfertilityR01HD067683 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEINER, ANNE ZWEIFEL · 2011 to 2015
$2.7M
An investigation of vitamin D in human fertility and early pregnancyR00HD079659 · NICHD · YALE UNIVERSITY · PI JUKIC, ANNE MARIE ZAURA · 2015 to 2017
$725k
Time to ConceiveR21HD060229 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STEINER, ANNE ZWEIFEL · 2009 to 2010
$407k
NICHD NIH HHS R00 HD079659NICHD NIH HHS R01 HD067683NICHD NIH HHS R21 HD060229
6 · The paper itself

Abstract

objectiveTo determine the association between antimüllerian hormone (AMH), a measure of ovarian reserve, and miscarriage among naturally conceived pregnancies.

designProspective cohort study.

settingNot applicable. PATIENT(S): Women (n = 533), between 30 and 44 years of age with no known history of infertility, polycystic ovarian syndrome, or endometriosis who conceived naturally. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Miscarriage, defined as an intrauterine pregnancy loss before 20 weeks' gestation. RESULT(S): After adjusting for maternal age, race, history of recurrent miscarriage, and obesity, risk of miscarriage decreased as AMH increased (risk ratio per unit increase in natural log of AMH = 0.83; 95% confidence interval [CI], 0.73, 0.94). Women with severely diminished ovarian reserve (AMH ≤ 0.4 ng/mL) miscarried at over twice the rate of women with an AMH ≥ 1 ng/mL (hazard ratio, 2.3; 95% CI, 1.3, 4.3). CONCLUSION(S): AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.

Indexed as

Abortion, SpontaneousAdultAnti-Mullerian HormoneBiomarkersCohort StudiesFemaleFertilizationHumansPregnancyPregnancy Trimester, FirstPregnancy Trimester, SecondPrognosisRisk FactorsAnti-Mullerian HormoneBiomarkersAntimüllerian hormonediminished ovarian reservemiscarriagepregnancy loss

Identifiers

PMID29871793
PMCPMC6063511
OpenAlexW2805680474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.