Evidence map›Paper›PMID 29871712›Full record

ArticlePsychological medicine2019

Accelerated alcohol use across adolescence predicts early adult symptoms of alcohol use disorder via reward-related neural function.

Rebecca Waller, Laura Murray, Daniel S Shaw, Erika E Forbes, Luke W Hyde

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Family-based prevention programmes for alcohol use in young people.The Cochrane database of systematic reviews · 2019
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  19. Individual Variables Involved in Perceived Pressure for Adolescent Drinking.International journal of environmental research and public health · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rebecca WallerDepartment of Psychology,University of Michigan,Ann Arbor,USA.ORCID 0000-0002-5069-1183
Laura MurrayDepartment of Psychology,University of Michigan,Ann Arbor,USA.
Daniel S ShawDepartment of Psychology,University of Pittsburgh,Pittsburgh,USA.
Erika E ForbesDepartment of Psychology,University of Pittsburgh,Pittsburgh,USA.
Luke W HydeDepartment of Psychology,University of Michigan,Ann Arbor,USA.
University of Michigan · USUniversity of Pittsburgh · US

Funding

MULTIDISCIPLINARY ALCOHOLISM RESEARCH TRAINING PROGRAMT32AA007477 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maureen A. Walton · 1990 to 2026
$7.4M
PRECURSORS OF ANTISOCIAL BEHAVIOR--FOLLOW UP TO AGE 6R01MH050907 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHAW, DANIEL S · 1994 to 2008
$5.1M
Substance Use in Young Men: Genes, Brain Function & Early Social DevelopmentR01DA026222 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FORBES, ERIKA E, SHAW, DANIEL S · 2009 to 2013
$4.0M
NIAAA NIH HHS T32 AA007477NIDA NIH HHS R01 DA026222NIMH NIH HHS R01 MH050907
6 · The paper itself

Abstract

backgroundAlcohol use is commonly initiated during adolescence, with earlier onset known to increase the risk for alcohol use disorder (AUD). Altered function in neural reward circuitry is thought to increase the risk for AUD. To test the hypothesis that adolescent alcohol misuse primes the brain for alcohol-related psychopathology in early adulthood, we examined whether adolescent alcohol consumption rates predicted reward responsivity in the ventral striatum (VS), and in turn, AUD symptoms in adulthood.

methodsA total of 139 low income, racially diverse urban males reported on their alcohol use at ages 11, 12, 15, and 17; completed self-reports of personality, psychiatric interviews, and a functional magnetic resonance imaging (fMRI) scan at age 20; and completed a psychiatric interview at age 22. We measured adolescent alcohol use trajectories using latent growth curve modeling and measured neural responses to monetary reward using a VS region of interest. We tested indirect effects of adolescent alcohol use on AUD symptoms at age 22 via VS reward-related reactivity at age 20.

resultsGreater acceleration in adolescent alcohol use predicted increased VS response during reward anticipation at age 20. VS reactivity to reward anticipation at age 20 predicted AUD symptoms at age 22, over and above concurrent symptoms. Accelerated adolescent alcohol use predicted AUD symptoms in early adulthood via greater VS reactivity to reward anticipation.

conclusionsProspective findings support a pathway through which adolescent alcohol use increases the risk for AUD in early adulthood by impacting reward-related neural functioning. These results highlight increased VS reward-related reactivity as a biomarker for AUD vulnerability.

Indexed as

AdolescentAlcoholismChildFunctional NeuroimagingHumansMagnetic Resonance ImagingMaleRewardRisk FactorsUnderage DrinkingVentral StriatumYoung AdultAdolescencealcohol use disorderfMRIprospectiverewardtrajectory

Identifiers

PMID29871712
PMCPMC7066874
OpenAlexW2805668178

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.