Evidence map›Paper›PMID 29871673›Full record

ArticleTrials2018

'Test n Treat (TnT)'- Rapid testing and same-day, on-site treatment to reduce rates of chlamydia in sexually active further education college students: study protocol for a cluster randomised feasibility trial.

Sarah Kerry-Barnard, Charlotte Fleming, Fiona Reid, Rachel Phillips, Vari M Drennan, Elisabeth J Adams, Wendy Majewska, Anjella Balendra, Emma Harding-Esch, Emma Cousins and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Sarah Kerry-BarnardPopulation Health Research Institute, St George's, University of London, London, SW17ORE, UK.
Charlotte FlemingPopulation Health Research Institute, St George's, University of London, London, SW17ORE, UK.
Fiona ReidDepartment of Primary Care and Public Health Sciences, King's College London, 4th Floor, Addison House, Guy's Campus, London, SE1 1UL, UK.
Rachel PhillipsDepartment of Primary Care and Public Health Sciences, King's College London, 4th Floor, Addison House, Guy's Campus, London, SE1 1UL, UK.
Vari M DrennanCentre for Health and Social Care Research, Kingston University and St George's University of London, London, SW17ORE, UK.
Elisabeth J AdamsAquarius Population Health Limited, 58a Highgate High Street, London, N6 5HX, UK.
Wendy MajewskaWEM Consultancy Ltd., 96 Tantallon Road, London, SW12 8DH, UK.
Anjella BalendraPopulation Health Research Institute, St George's, University of London, London, SW17ORE, UK.
Emma Harding-EschInfection and Immunity, St George's, University of London, London, SW17ORE, UK.
Emma CousinsInfection and Immunity, St George's, University of London, London, SW17ORE, UK.
S Tariq SadiqInfection and Immunity, St George's, University of London, London, SW17ORE, UK.
Pippa OakeshottPopulation Health Research Institute, St George's, University of London, London, SW17ORE, UK. oakeshot@sgul.ac.uk.ORCID http://orcid.org/0000-0003-2568-8211
St George's, University of London · GBKing's College London · GB21c Consultancy (United Kingdom) · GBAquarius Population Health · GB

Funding

British Medical Association TP Gunton 2017Department of Health PB-PG-1014-35007Medical Research Council G0901608National Institute for Health Research PB-PG-1014-35007Wellcome TrustWellcome Trust 204809/Z/16/Z
6 · The paper itself

Abstract

backgroundSexually active young people attending London further education (FE) colleges have high rates of chlamydia, but screening rates are low. We will conduct a cluster randomised feasibility trial of frequent, rapid, on-site chlamydia testing and same-day treatment (Test and Treat (TnT)) in six FE colleges (with parallel qualitative and economic assessments) to assess the feasibility of conducting a future trial to investigate if TnT reduces chlamydia rates.

methodsWe will recruit 80 sexually active students aged 16-24 years from public areas at each of six colleges. All participants (total n = 480) will be asked to provide samples (urine for males, self-taken vaginal swabs for females) and complete questionnaires on sexual lifestyle and healthcare use at baseline and after 7 months. Participants will be informed that baseline samples will not be tested for 7 months and be advised to get screened separately. Colleges will be randomly allocated to the intervention (TnT) or the control group (no TnT). One and 4 months after recruitment, participants at each intervention college (n = 3) will be texted and invited for on-site chlamydia tests using the 90-min Cepheid GeneXpert system. Students with positive results will be asked to see a visiting nurse health adviser for same-day treatment and partner notification, (backed by genitourinary medicine follow-up). Participants in control colleges (n = 3) will receive 'thank you' texts 1 and 4 months after recruitment. Seven months after recruitment, participants from both groups will be invited to complete questionnaires and provide samples for TnT. All samples will be tested, and same-day treatment offered to students with positive results. Acceptability of TnT will be assessed by qualitative interviews of purposively sampled students (n = 30) and college staff (n = 12). We will collect data on costs of TnT and usual healthcare. DISCUSSION: Findings will provide key values to inform feasibility, sample size and timescales of a future definitive trial of TnT in FE colleges, including: Recruitment rates TnT uptake rates Follow-up rates Prevalence of chlamydia in participants at baseline and 7 months Acceptability of TnT to students and college staff Estimate of the cost per person screened/treated in TnT versus usual care

trial registrationInternational Standard Randomised Controlled Trials Registry, ID: ISRCTN58038795 , Registered on 31 August 2016.

Indexed as

Bacteriological TechniquesSexual BehaviorStudent Health ServicesAdolescentChlamydia InfectionsFeasibility StudiesFemaleHumansLondonMaleMulticenter Studies as TopicPatient SatisfactionPredictive Value of TestsRandomized Controlled Trials as TopicStudentsSurveys and QuestionnairesCluster randomisedFeasibility trialFurther education collegesRapid chlamydia testsScreeningTest and treatYoung people

Identifiers

PMID29871673
PMCPMC5989383
OpenAlexW2806877773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.