ArticleGenome biology2018
SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.
Article in Genome biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Cell-specific responses of Anopheles gambiae fat body to blood feeding and infection at single-nuclei resolution.Nature communications · 2026Article
- Studying relative RNA localization from nucleus to the cytosol.NAR genomics and bioinformatics · 2025Article
- Segger: Fast and accurate cell segmentation of imaging-based spatial transcriptomics data.bioRxiv : the preprint server for biology · 2025Article
- Multi-Omics Profiling Unveils the Complexity and Dynamics of Immune Infiltrates in Intrahepatic Cholangiocarcinoma.Biology · 2024Article
- High-throughput mechanical phenotyping and transcriptomics of single cells.Nature communications · 2024Article
- Fine-grained cell-type specific association studies with human bulk brain data using a large single-nucleus RNA sequencing based reference panel.Scientific reports · 2023Article
- Single-Cell RNA Sequencing and Its Applications in the Study of Psychiatric Disorders.Biological psychiatry global open science · 2023Review
- Single-Cell Molecular Barcoding to Decode Multimodal Information Defining Cell States.Molecules and cells · 2023Review
- Isotachophoresis: Theory and Microfluidic Applications.Chemical reviews · 2022Review
- Recent Advances in Microscale Electroporation.Chemical reviews · 2022Review
- Gut mucosa dissociation protocols influence cell type proportions and single-cell gene expression levels.Scientific reports · 2022Article
- Subcellular Transcriptomics and Proteomics: A Comparative Methods Review.Molecular & cellular proteomics : MCP · 2022Review
- Application of RNA subcellular fraction estimation method to explore RNA localization regulation.G3 (Bethesda, Md.) · 2022Article
- Refining the Molecular Framework for Pancreatic Cancer with Single-cell and Spatial Technologies.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Review
- Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy.Nature communications · 2021Article
- Multimodal detection of protein isoforms and nucleic acids from low starting cell numbers.Lab on a chip · 2021Article
- Tissue-specific transcriptome profiling of the Arabidopsis inflorescence stem reveals local cellular signatures.The Plant cell · 2021Article
- NanoSINC-seq dissects the isoform diversity in subcellular compartments of single cells.Science advances · 2021Article
- The enteric nervous system: the hub in a star network.Nature reviews. Gastroenterology & hepatology · 2020Article
- Single cell transcriptome profiling of the human alcohol-dependent brain.Human molecular genetics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
We report a microfluidic system that physically separates nuclear RNA (nucRNA) and cytoplasmic RNA (cytRNA) from a single cell and enables single-cell integrated nucRNA and cytRNA-sequencing (SINC-seq). SINC-seq constructs two individual RNA-seq libraries, nucRNA and cytRNA, per cell, quantifies gene expression in the subcellular compartments, and combines them to create novel single-cell RNA-seq data. Leveraging SINC-seq, we discover distinct natures of correlation among cytRNA and nucRNA that reflect the transient physiological state of single cells. These data provide unique insights into the regulatory network of messenger RNA from the nucleus toward the cytoplasm at the single-cell level.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.