Evidence map›Paper›PMID 29870951›Full record

SynthesisNeurobiology of aging2018

Association of telomere length with general cognitive trajectories: a meta-analysis of four prospective cohort studies.

Yiqiang Zhan, Mark S Clements, Rosebud O Roberts, Maria Vassilaki, Brooke R Druliner, Lisa A Boardman, Ronald C Petersen, Chandra A Reynolds, Nancy L Pedersen, Sara Hägg

Abstract readMeta-Analysis
In one paragraph

Synthesis in Neurobiology of aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Finding biomarkers of experience in animals.Journal of animal science and biotechnology · 2024
    Review
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Short Leukocyte Telomeres, But Not Telomere Attrition Rates, Predict Memory Decline in the 20-Year Longitudinal Betula Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yiqiang ZhanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: Yiqiang.zhan@ki.se.
Mark S ClementsDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Rosebud O RobertsDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Maria VassilakiDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Brooke R DrulinerDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Lisa A BoardmanDepartment of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Ronald C PetersenDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Chandra A ReynoldsDepartment of Psychology, University of California, Riverside, CA, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
ROCHESTER EPIDEMIOLOGY PROJECTR01AR030582 · NIAMS · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A · 1986 to 2009
$5.1M
Epigenetic Mediation of Adverse Social Context on Stress Response, Socioemotional Development, and Health in a Population-based Study of Minority and Low SES Children and AdolescentsR01MD011716 · NIMHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MITCHELL, COLTER M.S. · 2017 to 2022
$4.6M
Individualizing colorectal cancer patient care using the host and tumor telomere phenotypeR01CA204013 · NCI · MAYO CLINIC ROCHESTER · PI BOARDMAN, LISA ALLYN · 2016 to 2020
$3.2M
GENETIC &ENVIRONMENTAL INFLUENCES--BIOBEHAVIORAL AGINGR01AG010175 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 1992 to 2006
$2.8M
Genomics for Social Scientists: 2022-2027R25AG053227 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, COLTER M.S. MITCHELL · 2016 to 2026
$1.6M
Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease riskR01AG028555 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI REYNOLDS, CHANDRA A · 2007 to 2010
$1.1M
NCI NIH HHS R01 CA204013NIAMS NIH HHS R01 AR030582NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG010175NIA NIH HHS R01 AG028555NIA NIH HHS R01 AG034676NIA NIH HHS R25 AG053227NIA NIH HHS RC4 AG039029NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG009740NIMHD NIH HHS R01 MD011716
6 · The paper itself

Abstract

To investigate the association of telomere length (TL) with trajectories of general cognitive abilities, we used data on 5955 participants from the Sex Differences in Health and Aging Study and the Swedish Adoption/Twin Study of Aging in Sweden, and the Mayo Clinic Study of Aging, and the Health and Retirement Study in the United States. TL was measured at baseline, while general cognitive ability was assessed repeatedly up to 7 occasions. Latent growth curve models were used to examine the associations. One standard deviation increase of TL was associated with 0.021 unit increase (95% confidence interval [CI]: 0.001, 0.042) of standardized mean general cognitive ability. After controlling for sex, the point estimate remained similar (0.019) with a wider CI (95% CI: -0.002, 0.039). The association was attenuated with adjustment for educational attainment (0.009, 95% CI: -0.009, 0.028). No strong evidence was observed for the association of TL and decline in general cognitive ability. Longer TL was associated with higher general cognitive ability levels in the age-adjusted models but not in the models including all covariates, nor with cognitive decline.

Indexed as

Cognitive AgingAgedCognitionFemaleHumansLongitudinal StudiesMaleProspective StudiesSwedenTelomereTwinsBiological agingCognitionCognitive agingTelomere

Identifiers

PMID29870951
PMCPMC6064381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.