Evidence map›Paper›PMID 29870755›Full record

ArticleMolecular and cellular endocrinology2018

C/EBPβ LIP and c-Jun synergize to regulate expression of the murine progesterone receptor.

Weizhong Wang, Han Ngoc Do, Mark D Aupperlee, Srinivasan Durairaj, Emily E Flynn, Richard J Miksicek, Sandra Z Haslam, Richard C Schwartz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Weizhong WangDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA.
Han Ngoc DoCell and Molecular Biology Program, Michigan State University, East Lansing, MI, 48824, USA.
Mark D AupperleeDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA; Breast Cancer and the Environment Research Program, Michigan State University, East Lansing, MI, 48824, USA.
Srinivasan DurairajDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Emily E FlynnGenetics Program, Michigan State University, East Lansing, MI, 48824, USA.
Richard J MiksicekDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA.
Sandra Z HaslamDepartment of Physiology, Michigan State University, East Lansing, MI, 48824, USA; Breast Cancer and the Environment Research Program, Michigan State University, East Lansing, MI, 48824, USA.
Richard C SchwartzDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, 48824, USA; Breast Cancer and the Environment Research Program, Michigan State University, East Lansing, MI, 48824, USA. Electronic address: schwart9@msu.edu.
Michigan State University · US

Funding

Breast Cancer and the Environment Research CenterU01ES012800 · NIEHS · MICHIGAN STATE UNIVERSITY · PI HASLAM, SANDRA Z · 2003 to 2009
$5.6M
Mammary carcinogenesis: pubertal and adult effects of high fat diet+oxybenzoneU01ES026119 · NIEHS · MICHIGAN STATE UNIVERSITY · PI SCHWARTZ, RICHARD C · 2015 to 2019
$4.1M
Pubertal high fat diet: effects on inflammation, mammary development and cancerU01ES019434 · NIEHS · MICHIGAN STATE UNIVERSITY · PI HASLAM, SANDRA Z · 2010 to 2014
$2.3M
NIEHS NIH HHS U01 ES012800NIEHS NIH HHS U01 ES019434NIEHS NIH HHS U01 ES026119
6 · The paper itself

Abstract

CCAAT/enhancer binding protein β (C/EBPβ) is required for murine mammary ductal morphogenesis and alveologenesis. Progesterone is critical for proliferation and alveologenesis in adult mammary glands, and there is a similar requirement for progesterone receptor isoform B (PRB) in alveologenesis. We examined C/EBPβ regulation of PR expression. All three C/EBPβ isoforms, including typically inhibitory LIP, transactivated the PR promoter. LIP, particularly, strongly synergized with c-Jun to drive PR transcription. Endogenous C/EBPβ and c-Jun stimulated a PR promoter-reporter and these two factors showed promoter occupancy on the endogenous PR gene. Additionally, LIP overexpression elevated endogenous PR protein expression. In pregnancy, both PRB and the relative abundance of LIP among C/EBPβ isoforms increase. Consistent with a role in PRB expression, in vivo C/EBPβ and PR isoform A expression showed mutually exclusive localization in mammary epithelium, while C/EBPβ and PRB largely co-localized. We suggest a critical role for C/EBPβ, particularly LIP, in PRB expression.

Indexed as

Gene Expression RegulationAnimalsCCAAT-Enhancer-Binding Protein-betaCell LineFemaleGenes, ReporterMice, Inbred BALB CPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-junReceptors, ProgesteroneCCAAT-Enhancer-Binding Protein-betaProto-Oncogene Proteins c-junReceptors, ProgesteroneC/EBPβLIPc-JunProgesterone receptorSynergistic regulationTranscription

Identifiers

PMID29870755
PMCPMC6153074
OpenAlexW2807218895

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.