Evidence map›Paper›PMID 29870679›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2018

A novel triple-tracer approach to assess postprandial protein turnover.

Antoinette Moran, Gianna Toffolo, Michele Schiavon, Adrian Vella, Katherine Klaus, Claudio Cobelli, K Sreekumaran Nair

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Exogenous insulin does not reduce protein catabolism in pre-diabetic cystic fibrosis patients: A randomized clinical trial.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Trial
  2. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Antoinette MoranDepartment of Pediatrics, University of Minnesota , Minneapolis, Minnesota.ORCID 0000-0002-2694-5147
Gianna ToffoloDepartment of Electronics and Informatics, University of Padova , Padova , Italy.
Michele SchiavonDepartment of Electronics and Informatics, University of Padova , Padova , Italy.
Adrian VellaDivision of Endocrinology, Mayo Clinic , Rochester, Minnesota.
Katherine KlausDivision of Endocrinology, Mayo Clinic , Rochester, Minnesota.
Claudio CobelliDepartment of Electronics and Informatics, University of Padova , Padova , Italy.
K Sreekumaran NairDivision of Endocrinology, Mayo Clinic , Rochester, Minnesota.
Mayo Clinic · USUniversity of Padua · ITUniversity of Minnesota · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
TECHNOLOGY NMR SPECTROSCOPYU24DK100469 · NIDDK · MAYO CLINIC ROCHESTER · PI NAIR, K SREEKUMARAN · 2013 to 2017
$9.0M
The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic CF PatientsR01DK101402 · NIDDK · UNIVERSITY OF MINNESOTA · PI MORAN, ANTOINETTE M. · 2015 to 2019
$3.5M
NCATS NIH HHS UL1 TR000114NIDDK NIH HHS R01 DK101402NIDDK NIH HHS U24 DK100469
6 · The paper itself

Abstract

Insulin and nutrients have profound effects on proteome homeostasis. Currently no reliable methods are available to measure postprandial protein turnover. A triple-tracer method was developed using phenylalanine stable isotope tracers to estimate appearance rates of ingested (R

Indexed as

Carbon IsotopesDeuteriumFastingFemaleHealthy VolunteersHumansMaleNitrogen IsotopesPhenylalaninePostprandial PeriodProteinsProteostasisYoung AdultCarbon-13Carbon IsotopesDeuteriumNitrogen-15Nitrogen IsotopesPhenylalanineProteinsprotein catabolismprotein turnoverstable isotopes

Identifiers

PMID29870679
PMCPMC6230707
OpenAlexW2806295542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.